Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders
Sankar A, Ziersen S, Ozenne B, Beaman E, Dam V, Fisher P, Knudsen G, Kessing L, Frokjaer V, Miskowiak K. Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders. EClinicalMedicine 2023, 58: 101927. PMID: 37007740, PMCID: PMC10050788, DOI: 10.1016/j.eclinm.2023.101927.Peer-Reviewed Original ResearchSocio-demographic conditionsPsychiatric hospitalAffective disordersNeurocognitive impairmentDepressive disorderExecutive functionVerbal memoryNeurocognitive functionNational population-based registersPopulation-based registersAssociation of neurocognitionVerbal memory domainSocio-demographic indicatorsStudies of neurocognitionClinically significant impairmentFuture hospitalsDepression severityMemory domainCox regression modelsIllness durationNeurocognitive assessmentEmployment outcomesSecondary outcomesSignificant impairmentStudy inclusionDeep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
Jensen K, Dam V, Ganz M, Fisher P, Ip C, Sankar A, Marstrand-Joergensen M, Ozenne B, Osler M, Penninx B, Pinborg L, Frokjaer V, Knudsen G, Jørgensen M. Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort. BMC Psychiatry 2023, 23: 151. PMID: 36894940, PMCID: PMC9999625, DOI: 10.1186/s12888-023-04618-x.Peer-Reviewed Original ResearchConceptsQuick Inventory of Depressive SymptomatologyFirst-episode depressionTreatment packageFirst-episode MDD patientsInventory of Depressive SymptomatologyBackgroundMajor depressive disorderSecond-line antidepressantsHeterogeneous brain disordersMarkers of treatment responseMedication side effectsMDD patientsDepressive disorderDepression severityDepressive symptomatologyPrecision psychiatrySymptom ChecklistClinical outcomesNeuroimaging dataBrain positron emission tomographyPublic outpatient clinicsDisability ScalePositron emission tomographyBrain disordersEffect of treatment choiceDepression