2016
Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors
Saucier-Sawyer JK, Seo YE, Gaudin A, Quijano E, Song E, Sawyer AJ, Deng Y, Huttner A, Saltzman WM. Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors. Journal Of Controlled Release 2016, 232: 103-112. PMID: 27063424, PMCID: PMC4893898, DOI: 10.1016/j.jconrel.2016.04.006.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryBlood-brain barrierBrain-penetrating nanoparticlesIntracranial tumorsBrain tumorsGlioblastoma multiformeHealthy brainMain tumor massFatal brain tumorPresence of tumorBrain tumor treatmentLocal recurrenceInfusion sitePeritumoral tissuesTumor massCED infusionIndividual tumorsTumorsNecrotic regionsTumor treatmentLocal administrationHeterogeneous distribution patternAdministrationBrainCell targeting
2012
Meningiomas include an antigen-experienced B cell infiltrate that produces antibodies directed to tumor antigens (127.36)
OConnor K, Fang L, Meizlish M, Anderson R, Bruce J, Huttner A, Lovato L. Meningiomas include an antigen-experienced B cell infiltrate that produces antibodies directed to tumor antigens (127.36). The Journal Of Immunology 2012, 188: 127.36-127.36. DOI: 10.4049/jimmunol.188.supp.127.36.Peer-Reviewed Original ResearchB-cell infiltratesCell infiltrateB cellsTumor antigensTumor-infiltrating B cellsAntigen-driven B cell responsesSpecific humoral immune responseCommon adult neoplasmImmune cell infiltratesB cell clonal expansionB cell responsesHumoral immune responseMemory B cellsCentral nervous systemCell clonal expansionB cell repertoireB cell maturationSignificant somatic mutationsDifferentiated plasma cellsImmune infiltratesAntigen experiencePlasma cellsImmune responseIntracranial tumorsCell repertoire