2014
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine 2014, 6: 248ra107. PMID: 25100741, PMCID: PMC4388137, DOI: 10.1126/scitranslmed.3008879.Peer-Reviewed Original ResearchConceptsCervical lymph nodesCentral nervous systemB cellsCerebrospinal fluidLymph nodesMultiple sclerosisLymphoid tissueCNS of patientsCNS B cellsAntigen-experienced B cellsMultiple sclerosis brainSecondary lymphoid tissuesB cell compartmentB cell trafficB cell maturationImmunomodulatory therapyImmune infiltratesPeripheral bloodInflammatory diseasesLymphocyte transmigrationPeripheral tissuesNervous systemMembers of clonesCell maturationCell traffic
2013
The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM, O'Connor KC. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro-Oncology 2013, 15: 1479-1490. PMID: 23978377, PMCID: PMC3813416, DOI: 10.1093/neuonc/not110.Peer-Reviewed Original ResearchConceptsTumor-infiltrating B cellsImmune cell infiltratesT cell repertoireCell infiltrateB cellsT cellsCell repertoireAntigen experienceImmune checkpoint molecules PD-1Memory/effector T cellsCheckpoint molecules PD-1Antigen-driven B cell responsesEffector T cell populationsTumor microenvironmentT-cell infiltratesRegulatory T cellsEffector T cellsT-cell phenotypeT cell populationsB cell responsesPeripheral blood lymphocytesAntigen-experienced CD4Cell populationsB cell populationsB cell repertoire
2012
Meningiomas include an antigen-experienced B cell infiltrate that produces antibodies directed to tumor antigens (127.36)
OConnor K, Fang L, Meizlish M, Anderson R, Bruce J, Huttner A, Lovato L. Meningiomas include an antigen-experienced B cell infiltrate that produces antibodies directed to tumor antigens (127.36). The Journal Of Immunology 2012, 188: 127.36-127.36. DOI: 10.4049/jimmunol.188.supp.127.36.Peer-Reviewed Original ResearchB-cell infiltratesCell infiltrateB cellsTumor antigensTumor-infiltrating B cellsAntigen-driven B cell responsesSpecific humoral immune responseCommon adult neoplasmImmune cell infiltratesB cell clonal expansionB cell responsesHumoral immune responseMemory B cellsCentral nervous systemCell clonal expansionB cell repertoireB cell maturationSignificant somatic mutationsDifferentiated plasma cellsImmune infiltratesAntigen experiencePlasma cellsImmune responseIntracranial tumorsCell repertoire