Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins
Raghupathy R, Anilkumar A, Polley A, Singh P, Yadav M, Johnson C, Suryawanshi S, Saikam V, Sawant S, Panda A, Guo Z, Vishwakarma R, Rao M, Mayor S. Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins. Cell 2015, 161: 581-594. PMID: 25910209, PMCID: PMC4651428, DOI: 10.1016/j.cell.2015.03.048.Peer-Reviewed Original ResearchConceptsLive cell membranesCell membraneDynamic actin filamentsInner leafletLiquid-ordered phaseAtom molecular dynamics simulationsActin filamentsLipid domainsGeneral mechanismTransbilayer couplingOpposite leafletLipid clustersAcyl chain lipidsProteinPhosphatidylserineLipidsMembraneMolecular dynamics simulationsLeafletsNanoclusteringCorresponding lipidsDomainGPIInteractionDynamics simulations