2021
An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy
Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.Peer-Reviewed Original ResearchConceptsMemorial Sloan-Kettering Cancer CenterCore biopsyPredictive valueDiagnostic accuracyProstate core needle biopsiesCore needle biopsySurgical pathology practiceNegative predictive valueProstate core biopsiesPositive predictive valueProstate cancer detectionStrong diagnostic accuracyPoor quality scansCancer detectionCancer CenterProstate biopsyLeading causeNeedle biopsyTransrectal approachProstate cancerProstatic adenocarcinomaProstate carcinomaBiopsyPathology practiceProstateHigh-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests
Zuo T, Levi AW, Lin Q, Abi-Raad R, Adeniran AJ, Cai G. High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests. American Journal Of Clinical Pathology 2021, 156: 569-576. PMID: 33728437, DOI: 10.1093/ajcp/aqaa265.Peer-Reviewed Original ResearchConceptsPositive hrHPV resultsCervical intraepithelial neoplasiaHrHPV resultsHrHPV testingCIN2-3Intraepithelial neoplasiaPapanicolaou testCervical carcinomaHigh risk human papillomavirus statusHigh-risk human papillomavirus (hrHPV) testingHigh-grade cervical intraepithelial neoplasiaLow-grade cervical intraepithelial neoplasiaHuman papillomavirus testingHuman papillomavirus (HPV) statusManagement of patientsAbnormal glandular cellsHPV genotypesHPV subtypesAGC casesPap testFollow-upHistologic followHigh lesionsType 16Reactive changes
2018
Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies
Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.Peer-Reviewed Original ResearchConceptsPI-RADSv2 scoreDecipher scoreProstate Imaging ReportingDecipher testingTargeted biopsiesRadical prostatectomyData System version 2 (PI-RADS v2) scoreFavorable intermediate-risk prostate cancerIntermediate-risk prostate cancer patientsGleason Grade Group 1Imaging ReportingIntermediate-risk prostate cancerMultivariable logistic regression analysisHigh-risk diseasePI-RADS 4Grade group 1Gleason grade groupProstate cancer patientsMultiparametric magnetic resonancePI-RADS scoreVersion 2 scoreData System scoreLogistic regression analysisSignificant differencesPI-RADS category
2017
Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy
Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingSignificant prostate cancerProstate cancerNegative predictive valueMagnetic resonance imagingSystematic TRUSNegative mpMRIProstate biopsyNegative multiparametric magnetic resonance imagingPredictive valueResonance imagingClinically Significant Prostate CancerDynamic contrast enhancement sequencesTemplate mapping biopsyPrior negative biopsySystematic prostate biopsyOverall cancer detectionProstate-specific antigenTemplate prostate biopsyProstate cancer detectionDiffusion-weighted imagingCancer detectionBiopsy naïveMapping biopsyProstate volume
2015
Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin
Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/ajcpcza4pszcfhq4.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCobas 4800 systemRoche cobas 4800 systemMetastatic squamous cell carcinomaFine needle aspiratesHuman papillomavirusHR-HPVCell carcinomaHPV 16High-risk (HR) HPVSquamous cell carcinoma originatingHigh-risk human papillomavirusNeck squamous cell carcinomaHPV 16/18 genotypesHR-HPV testingHR-HPV detectionHR-HPV resultsCorresponding histologic specimensLeft parapharyngeal massElectronic health recordsCarcinoma originatingMediastinal lymphadenopathyNegative HNSCCProspective studyHistologic material
2014
Methylation of Twelve CpGs in Human Papillomavirus Type 16 (HPV16) as an Informative Biomarker for the Triage of Women Positive for HPV16 Infection
Brandsma JL, Harigopal M, Kiviat NB, Sun Y, Deng Y, Zelterman D, Lizardi PM, Shabanova VS, Levi A, Yaping T, Hu X, Feng Q. Methylation of Twelve CpGs in Human Papillomavirus Type 16 (HPV16) as an Informative Biomarker for the Triage of Women Positive for HPV16 Infection. Cancer Prevention Research 2014, 7: 526-533. PMID: 24556390, DOI: 10.1158/1940-6207.capr-13-0354.Peer-Reviewed Original ResearchConceptsCervical intraepithelial neoplasiaCytology samplesCutoff scoreColposcopy of womenCervical cancer preventionManagement of womenDetection of CIN3Cervical cytology samplesHuman papillomavirus type 16Human papillomavirus type 16 DNAMethylation biomarkersPapillomavirus type 16Histologic severityIntraepithelial neoplasiaCervical cancerHPV16 infectionCancer preventionDNA bisulfite sequencingType 16Prognostic potentialAccurate biomarkersProspective biomarkersScreening testInformative biomarkersBiomarkersPrior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study
Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA. Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study. Archives Of Pathology & Laboratory Medicine 2014, 139: 184-8. PMID: 24694342, DOI: 10.5858/arpa.2014-0028-oa.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerInvasive cervical carcinomaHrHPV testingCervical cancerCervical carcinomaHPV testingHistologic diagnosisPersistent high-risk human papillomavirus (HPV) infectionHigh-risk human papillomavirus (hrHPV) testingHigh-risk human papillomavirus infectionHigh-risk HPV testingPrimary HPV testingHuman papillomavirus testingHuman papillomavirus infectionRetrospective multicenter studyCervical epithelial lesionsCurrent screening guidelinesSquamous cell carcinomaHPV ratesPapillomavirus infectionMulticenter studyScreening guidelinesCell carcinomaPapanicolaou testSingle institution
2011
Comparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-447. PMID: 21350100, DOI: 10.1309/ajcp7tbn5vzuglzu.Peer-Reviewed Original ResearchConceptsAffirm VPIIIPap testPapanicolaou testRoutine Pap testRoutine Papanicolaou testCandida speciesSensitive diagnostic testInfectious vaginitisLarge academic institutionPatient populationTrichomonas infectionBacterial vaginosisCandida vaginitisG vaginalisT vaginalisStudy populationHigh incidenceDiagnostic testsMolecular testsPatientsVaginitisVaginalisMorphologic identificationVaginosisCandidiasis
2004
Urinary bladder biopsy with denuded mucosa: Denuding cystitis—Cytopathologic correlates
Parwani AV, Levi AW, Epstein JI, Ali SZ. Urinary bladder biopsy with denuded mucosa: Denuding cystitis—Cytopathologic correlates. Diagnostic Cytopathology 2004, 30: 297-300. PMID: 15108225, DOI: 10.1002/dc.10406.Peer-Reviewed Original ResearchConceptsHigh-grade urothelial carcinomaUrothelial carcinomaUrinary cytologyFollowing histologic subtypesUrinary bladder biopsiesPositive urinary cytologySurgical pathology filesInvasive urothelial carcinomaOptimal patient managementRecurrent urothelial carcinomaJohns Hopkins HospitalPatient agePathology filesHistologic subtypeBladder biopsiesHistologic diagnosisBladder mucosaFlat carcinomaSensitive modalityPatient managementCytologic diagnosisCystitisCytologic studyTissue biopsiesPatients
2003
Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens
Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens. Cancer 2003, 99: 191-197. PMID: 12925979, DOI: 10.1002/cncr.11507.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColposcopyCost-Benefit AnalysisDNA, ViralFemaleFollow-Up StudiesHumansMiddle AgedModels, StatisticalPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPatient Care PlanningPolymerase Chain ReactionPractice Guidelines as TopicSensitivity and SpecificityTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsAtypical squamous cellsHPV test resultsHigh-grade lesionsASCUS smearsHPV-positive smearsIntraepithelial lesionsSquamous cellsUndetermined significanceHuman papillomavirus (HPV) DNA testingASCUS interpretationHigh-risk HPV typesHPV-positive casesHPV DNA testingHigh-risk typesLiquid-based Pap smearsLow-grade lesionsDNA testingColposcopy triageHPV testingASCUS cytologyHPV typesPap smearMollaret's meningitis: Cytopathologic analysis of fourteen cases
Chan TY, Parwani AV, Levi AW, Ali SZ. Mollaret's meningitis: Cytopathologic analysis of fourteen cases. Diagnostic Cytopathology 2003, 28: 227-231. PMID: 12722116, DOI: 10.1002/dc.10261.Peer-Reviewed Original ResearchConceptsMollaret's meningitisRecurrent episodesPolymerase chain reactionPolymorphonuclear leukocytesMost common clinical presentationCerebrospinal fluid examinationCommon clinical presentationAppropriate clinical settingSmall mature lymphocytesHerpes simplex virus type 2 DNAHemosiderin-laden macrophagesCentral nervous systemVirus type 2 DNASole diagnostic modalityAseptic meningitisCSF examinationFluid examinationClinical presentationLymphoproliferative disordersMild feverClinical dataCytopathologic analysisDifferential diagnosisPlasma cellsDiagnostic modalities
2001
The pigmented “black” neuroendocrine tumor of the pancreas
Sehdev A, Levi A, Nadasdy T, Campbell K, Fishman E, Hruban R. The pigmented “black” neuroendocrine tumor of the pancreas. Cancer 2001, 92: 1984-1991. PMID: 11745274, DOI: 10.1002/1097-0142(20011001)92:7<1984::aid-cncr1718>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsMetastatic melanomaNeuroendocrine tumorsNeoplastic cellsIron stainIslet cell tumorsFontana-Masson stainPerineural invasionSecond patientHMB-45Large neoplasmsAdrenal glandCell tumorsIncidental findingBlack adenomaImmunohistochemical stainsPancreatic neoplasmsComputerized tomographySmall lipid inclusionsNeoplasmsTumorsPatientsUltrastructural examinationNeurosecretory granulesPancreasFontana-MassonCLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY
LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. PMID: 11458047, DOI: 10.1016/s0022-5347(05)65963-0.Peer-Reviewed Original ResearchConceptsCold cup biopsyHistory of carcinomaCup biopsyBladder biopsiesSubsequent carcinomaPertinent clinical featuresTissue fragmentsLow-grade papillary tumorsSpecific pathological featuresDiagnosis of carcinomaBenign urothelial cellsCystoscopic impressionPatients 22Intravesical chemotherapyClinical featuresBladder lesionsBladder neoplasmsPredictive factorsLoop biopsyPapillary tumorsPathological featuresTissue inflammationBladder carcinomaEpithelial denudationMiscellaneous conditions
2000
Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy
Levi A, Epstein J. Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy. The American Journal Of Surgical Pathology 2000, 24: 1039-1046. PMID: 10935644, DOI: 10.1097/00000478-200008000-00001.Peer-Reviewed Original ResearchConceptsNeedle biopsyProstatic adenocarcinomaSimple prostatectomyMalignant diagnosisHigh molecular weight keratinSurgical pathology filesBenign hyperplastic glandsJohns Hopkins HospitalDiagnosis of cancerPathology filesTransurethral resectionPapillary infoldingsHyperplastic glandsAtypical glandsImmunohistochemical stainsConsult casesWeight keratinBiopsyCorpora amylaceaFrequent nucleoliHistologic attributesAdenocarcinomaBenign featuresCancerNuclear enlargement