2014
MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR
Zhang L, Bartley CM, Gong X, Hsieh LS, Lin TV, Feliciano DM, Bordey A. MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR. Neuron 2014, 84: 78-91. PMID: 25277454, PMCID: PMC4185153, DOI: 10.1016/j.neuron.2014.09.009.Peer-Reviewed Original ResearchConceptsDendritic complexityFLNA overexpressionDendritic abnormalitiesFLNA expressionDendritic patterningComplex dendritic arborsWild-type neuronsFilamin ADendritic arborsERK1/2-dependent mannerDendritic defectsNeurological defectsMEK-ERK1/2NeuronsMTOR activityNeurodevelopmental disordersNeurodevelopmental diseasesProtein filamin AAbnormalitiesMTOROverexpression
2006
GFAP‐expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes
Liu X, Bolteus AJ, Balkin DM, Henschel O, Bordey A. GFAP‐expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia 2006, 54: 394-410. PMID: 16886203, DOI: 10.1002/glia.20392.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Transport System X-AGAnimalsAnimals, NewbornAstrocytesBiomarkersCell DifferentiationCell ShapeConnexinsEpendymaGlial Fibrillary Acidic ProteinGlutamic AcidGreen Fluorescent ProteinsMembrane PotentialsMiceMice, TransgenicOrgan Culture TechniquesPatch-Clamp TechniquesPhenotypePotassiumPotassium ChannelsRecombinant Fusion ProteinsStem CellsTelencephalonConceptsGlial fibrillary acidic proteinPostnatal subventricular zoneSubventricular zoneGFAP-expressing cellsRadial gliaAstroglial marker glial fibrillary acidic proteinGlial propertiesEpendymal cellsGlutamate transportersGLT-1 glutamate transporterMarker glial fibrillary acidic proteinAMPA-type glutamate receptorsFunctional glutamate transportersFibrillary acidic proteinHuman glial fibrillary acidic proteinAdult subventricular zoneConnexin 43 expressionGap junction couplingNeural stem cellsMicroM Ba2Acute slicesAstrocytic functionsGlutamate receptorsGlial phenotypeClamp recordings
2005
Assays for measuring extracellular GABA levels and cell migration rate in acute slices
Bolteus AJ, Garganta C, Bordey A. Assays for measuring extracellular GABA levels and cell migration rate in acute slices. Brain Research 2005, 14: 126-134. PMID: 15721818, DOI: 10.1016/j.brainresprot.2004.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological AssayCell MovementGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidImmunohistochemistryLateral VentriclesMass SpectrometryMembrane Transport ModulatorsMembrane Transport ProteinsMiceMicroscopy, VideoNeurochemistryNeuronsOrgan Culture TechniquesReceptors, GABAStem CellsTelencephalonConceptsRostral migratory streamSubventricular zoneEndogenous GABAGABA levelsGABA receptorsNeuronal precursorsCell migrationLocal GABA levelsExtracellular GABA levelsAcute brain slicesAdult rodent brainPostnatal subventricular zoneFuture therapeutic useNeuronal precursor migrationAcute slicesBrain slicesNeurotransmitter GABASVZ cellsOlfactory bulbRodent brainRMS explantsMigratory streamTherapeutic useNeural precursorsGABA