2003
Chemokine modulation of high‐conductance Ca2+‐sensitive K+ currents in microglia from human hippocampi
Bordey A, Spencer DD. Chemokine modulation of high‐conductance Ca2+‐sensitive K+ currents in microglia from human hippocampi. European Journal Of Neuroscience 2003, 18: 2893-2898. PMID: 14656339, DOI: 10.1111/j.1460-9568.2003.03021.x.Peer-Reviewed Original ResearchConceptsHigh-conductance Ca2MIP1-alphaAcute pathological processesNon-activated microgliaSensitive outward currentsPharmaco-resistant epilepsyPatch-clamp recordingsOutward current amplitudeHigh input resistanceChemokine modulationHippocampal slicesInjury siteBrain slicesChronic pathologiesMicrogliaEpileptic patientsAmeboid morphologyIntracellular Ca2Human hippocampusOutward currentsMigratory effectsInput resistancePositive labelingPathological processesMode of action
2002
Analysis of the K+ Current Profile of Mature Rat Oligodendrocytes in situ
Gipson K, Bordey A. Analysis of the K+ Current Profile of Mature Rat Oligodendrocytes in situ. The Journal Of Membrane Biology 2002, 189: 201-212. PMID: 12395285, DOI: 10.1007/s00232-002-1014-8.Peer-Reviewed Original Research
2000
Ion channel expression by astrocytes in situ: Comparison of different CNS regions
Bordey A, Sontheimer H. Ion channel expression by astrocytes in situ: Comparison of different CNS regions. Glia 2000, 30: 27-38. PMID: 10696142, DOI: 10.1002/(sici)1098-1136(200003)30:1<27::aid-glia4>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsBergmann glial cellsIon channel complementGlial cellsIon channel expressionDifferent CNS regionsCNS regionsChannel expressionPercentage of astrocytesTransient A-typeCerebellar Bergmann glial cellsChannel complementPatch-clamp recordingsVoltage-activated currentsPostnatal day 17Whole-cell currentsIon channelsVoltage-gated ion channelsBrain slicesRat astrocytesAstrocytesDay 17Low input resistanceInput resistanceCNSInitial recording
1994
SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell Line
Oury‐Donat F, Lefevre IA, Thurneyssen O, Gauthier T, Bordey A, Feltz P, Emonds‐Alt X, Le Fur G, Soubrie P. SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell Line. Journal Of Neurochemistry 1994, 62: 1399-1407. PMID: 7510780, DOI: 10.1046/j.1471-4159.1994.62041399.x.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytomaBinding, CompetitiveCalciumElectric ConductivityGenes, fosHumansInositol PhosphatesIodine RadioisotopesNeurokinin-1 Receptor AntagonistsPeptide FragmentsPiperidinesPotassiumPyrrolidonecarboxylic AcidQuinuclidinesReceptors, Neurokinin-1StereoisomerismSubstance PSuccinimidesTaurineTranscription, GeneticTumor Cells, CulturedConceptsSR 140333Substance PNK1 tachykinin receptor antagonistNK1 receptor activationHunter substance PNK1-selective agonistTachykinin receptor antagonistsInositol monophosphate formationNK1 tachykinin receptorsPotent nonpeptide antagonistHuman astrocytoma cell lineCell linesAstrocytoma cell linesPatch-clamp experimentsReceptor antagonistFormation of inositolTachykinin receptorsNK1 agonistU373MG cell linesCalcium mobilizationNonpeptide antagonistsRadioligand bindingReceptor activationOutward currentsMonophosphate formation