Featured Publications
Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda
Chang A, Nabbaale J, Okello E, Ssinabulya I, Barry M, Beaton A, Webel A, Longenecker C. Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda. Journal Of The American Heart Association 2020, 9: e015562. PMID: 32295465, PMCID: PMC7428530, DOI: 10.1161/jaha.119.015562.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAnticoagulantsComorbidityFemaleHealthcare DisparitiesHumansMaleMedication AdherenceOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesReproductive HealthRetention in CareRetrospective StudiesRheumatic Heart DiseaseRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeUgandaWomen's HealthYoung AdultConceptsRheumatic heart diseaseWomen of reproductive ageHeart diseaseReproductive ageClinical rheumatic heart diseaseRheumatic Heart Disease RegistryAdherence to guideline-based therapyNew York Heart Association class III-IV heart failurePrescription of warfarinRisk of cardiovascular complicationsCox proportional hazards modelsProportional hazards modelRetrospective cohort studyGuideline-based therapyAdherence ratesDisease RegistryCohort studyAnticoagulant prescriptionSub-Saharan AfricaAnticoagulant useCardiovascular complicationsClinical outcomesCompare comorbiditiesHazards modelHeart failure
2023
Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial
Chang A, Rahman M, Talukder A, Shah H, Mridha M, Hasan M, Sarker M, Geldsetzer P. Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial. Trials 2023, 24: 480. PMID: 37501102, PMCID: PMC10375753, DOI: 10.1186/s13063-023-07518-3.Peer-Reviewed Original ResearchConceptsLow-sodium salt substituteCommunity health workersCluster randomized controlled trialHealth workersRural BangladeshImplementing health interventionsBackgroundHigh blood pressureMonths post-interventionBlood pressureExcessive salt consumptionMiddle-income countriesRandomized controlled trialsBlood pressure improvementPublic health problemHigh blood pressureLow-sodium saltPost-interventionCommunity healthHealth interventionsMortality reductionSalt consumptionHealth consequencesHealth problemsBlood pressure-lowering interventionsControlled trials
2021
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis
Chen I, Vedula V, Malik S, Liang T, Chang A, Chung K, Sayed N, Tsao P, Giacomini J, Marsden A, Wu J. Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis. Circulation Cardiovascular Imaging 2021, 14: 1122-1132. PMID: 34915729, PMCID: PMC9206593, DOI: 10.1161/circimaging.121.012884.Peer-Reviewed Original ResearchConceptsAortic valve areaAortic stenosisNoncoronary cuspMale patientsCalcium scoreCoronary cuspValve areaNormal valvesEvaluation of aortic stenosisTranscatheter aortic valve replacementAortic valve replacementComputed tomography angiogramRight coronary cuspLeft coronary cuspNormal aortic valveRight coronary arteryAS severityValve replacementLeaflet thickeningOstial occlusionCalcification loadAortic valveLeaflet excursionCoronary arteryPatientsClinical Outcomes, Echocardiographic Findings, and Care Quality Metrics for People Living With Human Immunodeficiency Virus (HIV) and Rheumatic Heart Disease in Uganda
Chang A, Rwebembera J, Bendavid E, Okello E, Barry M, Beaton A, Haeffele C, Webel A, Kityo C, Longenecker C. Clinical Outcomes, Echocardiographic Findings, and Care Quality Metrics for People Living With Human Immunodeficiency Virus (HIV) and Rheumatic Heart Disease in Uganda. Clinical Infectious Diseases 2021, 74: 1543-1548. PMID: 34382644, DOI: 10.1093/cid/ciab681.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusRheumatic heart diseaseEchocardiographic findingsImmunodeficiency virusHeart diseaseClinical outcomesDiagnosis of human immunodeficiency virusPrescription ratesAge- and sex-matched cohortMedication prescription ratesLongitudinal outcomes of patientsCare quality metricsOutcomes of patientsMiddle-income countriesEpidemiology of patientsSex-matched cohortAll-cause mortalityStroke/transient ischemic attackRate of strokeMedian ageClinical careCardiovascular complicationsClinical characteristicsMultivariable adjustmentConcurrent diagnosis
2018
Association of Healthcare Plan with atrial fibrillation prescription patterns
Chang A, Askari M, Fan J, Heidenreich P, Ho P, Mahaffey K, Ullal A, Perino A, Turakhia M. Association of Healthcare Plan with atrial fibrillation prescription patterns. Clinical Cardiology 2018, 41: 1136-1143. PMID: 30098034, PMCID: PMC6489790, DOI: 10.1002/clc.23042.Peer-Reviewed Original ResearchConceptsNon-vitamin K-dependent oral anticoagulantsPrimary care physiciansAtrial fibrillationHealthcare planningOral anticoagulantsPlanned patientsOdds of OAC prescriptionAF diagnosisPrescription of oral anticoagulantsRhythm control agentsRhythm control medicationsRetrospective cohort studyAF treatment strategiesReceipt of therapyPharmaceutical claims databaseAssociated with lower useIndex AF diagnosisReceipt of medicationsOAC prescriptionMedian timeLogistic regression modelsAF therapyPrescription patternsTreatment strategiesCohort studyPatient and facility variation in costs of catheter ablation for atrial fibrillation
Perino A, Fan J, Schmitt S, Kaiser D, Heidenreich P, Narayan S, Wang P, Chang A, Turakhia M. Patient and facility variation in costs of catheter ablation for atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2018, 29: 1081-1088. PMID: 29864193, PMCID: PMC6469652, DOI: 10.1111/jce.13655.Peer-Reviewed Original Research