2024
Microbial transformation of dietary xenobiotics shapes gut microbiome composition
Culp E, Nelson N, Verdegaal A, Goodman A. Microbial transformation of dietary xenobiotics shapes gut microbiome composition. Cell 2024, 187: 6327-6345.e20. PMID: 39321800, PMCID: PMC11531382, DOI: 10.1016/j.cell.2024.08.038.Peer-Reviewed Original ResearchGut microbiomeHuman gut microbesGut microbiome compositionDiet-microbiome interactionsGut microbesCommunity compositionMicrobiome compositionMicrobial metabolismResponse to dietInterindividual variationMicrobiomeDietary xenobioticsMap interactionsGutMetabolic activityEnzymeXenobioticsDetoxificationGenesMicrobesResveratrolRemodelingTraitsInteractionVariation
2023
Infection leaves a genetic and functional mark on the gut population of a commensal bacterium
Tawk C, Lim B, Bencivenga-Barry N, Lees H, Ramos R, Cross J, Goodman A. Infection leaves a genetic and functional mark on the gut population of a commensal bacterium. Cell Host & Microbe 2023, 31: 811-826.e6. PMID: 37119822, PMCID: PMC10197903, DOI: 10.1016/j.chom.2023.04.005.Peer-Reviewed Original ResearchConceptsRapid genetic adaptationSingle nucleotide variantsMultiple phylaGenetic adaptationFunctional marksStable marksEnteric infectionsGene expressionPopulation dynamicsGut commensalsCommensal populationsMicrobiome compositionAbsence of infectionRapid selectionCitrobacter rodentiumFitnessGut populationsCommensal bacteriumInfected miceGastrointestinal infectionsGnotobiotic miceCommensalGut lumenDirect administrationVitamin B6