2017
Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome
Dehner C, Ruff W, Vieira S, Goodman A, Kriegel M. Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.184.7.Peer-Reviewed Original ResearchBALB/c miceAdaptive immune systemAntiphospholipid syndromeB cellsC miceT cellsCell epitopesImmune systemPathogenic T cell epitopesTetramer-positive T cellsCD4 memory T cellsMemory T cellsTNF-α ILAdaptive immune responsesT cell clonesT cell epitopesDose-responsive mannerHuman commensal bacteriumB-cell epitopesEpitope-specific monoclonal antibodiesIL-21Patient PBMCsLymph nodesGPI antibodiesAntigenic challenge
2016
Lupus T and B cell cross-reactivity between the human Ro60 autoantigen and Ro60 orthologs from the human microbiota
Greiling T, Dehner C, Renfroe S, Chen X, Vieira S, Ruff W, Goodman A, Wolin S, Kriegel M. Lupus T and B cell cross-reactivity between the human Ro60 autoantigen and Ro60 orthologs from the human microbiota. The Journal Of Immunology 2016, 196: 124.16-124.16. DOI: 10.4049/jimmunol.196.supp.124.16.Peer-Reviewed Original ResearchLupus patientsAnti-Ro60 antibodiesB cellsP. propionicumGerm-free miceGut commensalsHuman lupus patientsHuman microbiotaT cell clonesNovel therapeutic approachesSubset of skinAutoimmune TEarliest autoantibodiesLupus TRo60 antibodiesIgA antibodiesChronic autoimmunityMemory TSystemic autoimmunityHealthy controlsT cellsTherapeutic approachesPatientsSusceptible individualsAutoimmunity
2015
Cross‐reactivity of Gut Commensals and Autoantigen in Antiphospholipid Syndrome
Dehner C, Ruff W, Vieira S, Goodman A, Kriegel M. Cross‐reactivity of Gut Commensals and Autoantigen in Antiphospholipid Syndrome. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.142.4.Peer-Reviewed Original ResearchAntiphospholipid syndromeMemory T cellsAutoimmune disease modelsGut commensalsAdaptive immune responsesB cell reactivityB-cell epitopesPatient plasma samplesAPS pathogenesisAPS patientsPatient PBMCsUnknown etiologyCell reactivityControl subjectsT cellsImmune responseCell epitopesT cell librariesB cellsGut microbiotaWestern blot experimentsWestern blottingHuman autoantigensDisease modelsPlasma samples