2024
LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information
Dong Z, Jiang W, Li H, DeWan A, Zhao H. LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information. Briefings In Bioinformatics 2024, 25: bbae335. PMID: 38980374, PMCID: PMC11232466, DOI: 10.1093/bib/bbae335.Peer-Reviewed Original ResearchMeSH KeywordsGene-Environment InteractionGenome-Wide Association StudyHumansLinkage DisequilibriumModels, GeneticMultifactorial InheritancePhenotypePolymorphism, Single NucleotideConceptsHuman complex traitsComplex traitsGene-environment interactionsGene-environmentLinkage disequilibriumPhenotypic variance componentsPhenotypic varianceProportion of phenotypic varianceSummary statisticsEuropean ancestry subjectsUK Biobank dataAssociation summary statisticsComplete linkage disequilibriumControlled type I error ratesLD informationLD matrixVariance componentsBiobank dataType I error rateEuropean ancestrySample size increaseGenetic effectsTraitsE-I pairsSimulation study
2018
Gene-Gene and Gene-Environment Interactions
DeWan AT. Gene-Gene and Gene-Environment Interactions. Methods In Molecular Biology 2018, 1793: 89-110. PMID: 29876893, DOI: 10.1007/978-1-4939-7868-7_7.BooksConceptsComplex traitsGene-environment interactionsGenome-wide interaction analysisGenetic variantsGenetic architectureDense panelMultiple test correctionGene-GeneTest correctionExplicit testsTraitsHigher-order interactionsRare frequencyInteraction analysisVariantsInteractionSmall effect sizesReplicationInteraction resultsOrder interactions