2023
Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibition
2022
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review
Subramanian A, Weiss D, Nyhan K, Dewan A, Jukic A. Circulating miRNAs in the first trimester and pregnancy complications: a systematic review. Epigenetics 2022, 18: 2152615. PMID: 36503407, PMCID: PMC9980650, DOI: 10.1080/15592294.2022.2152615.Peer-Reviewed Original ResearchConceptsPregnancy complicationsSystematic reviewFirst trimesterMiR-520hPlacental originMiR-518bFuture pregnancy complicationsMost pregnancy complicationsFirst-trimester serumFirst trimester biomarkersPotential early biomarkersGestational hypertensionPreterm birthPlacental pathologyEarly biomarkersComplicationsEarly placentationPotential biomarkersPlasma miRNAsPreeclampsiaMiR-125bEarly detectionBiomarkersMiR-365aMost evidence