Featured Publications
The circadian neutrophil, inside-out
Ovadia S, Özcan A, Hidalgo A. The circadian neutrophil, inside-out. Journal Of Leukocyte Biology 2023, 113: 555-566. PMID: 36999376, PMCID: PMC10583762, DOI: 10.1093/jleuko/qiad038.Peer-Reviewed Original ResearchStrategies of neutrophil diversification
Palomino-Segura M, Sicilia J, Ballesteros I, Hidalgo A. Strategies of neutrophil diversification. Nature Immunology 2023, 24: 575-584. PMID: 36959290, PMCID: PMC10139675, DOI: 10.1038/s41590-023-01452-x.Peer-Reviewed Original ResearchBehavioural immune landscapes of inflammation
Crainiciuc G, Palomino-Segura M, Molina-Moreno M, Sicilia J, Aragones DG, Li JLY, Madurga R, Adrover JM, Aroca-Crevillén A, Martin-Salamanca S, del Valle AS, Castillo SD, Welch HCE, Soehnlein O, Graupera M, Sánchez-Cabo F, Zarbock A, Smithgall TE, Di Pilato M, Mempel TR, Tharaux PL, González SF, Ayuso-Sacido A, Ng LG, Calvo GF, González-Díaz I, Díaz-de-María F, Hidalgo A. Behavioural immune landscapes of inflammation. Nature 2022, 601: 415-421. PMID: 34987220, PMCID: PMC10022527, DOI: 10.1038/s41586-021-04263-y.Peer-Reviewed Original ResearchCo-option of Neutrophil Fates by Tissue Environments
Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A. Co-option of Neutrophil Fates by Tissue Environments. Cell 2020, 183: 1282-1297.e18. PMID: 33098771, DOI: 10.1016/j.cell.2020.10.003.Peer-Reviewed Original ResearchConceptsNeutrophil fateDepletion of neutrophilsHematopoietic recoveryVascular repairNeutrophil statesNeutrophil propertiesViral infectionNeutrophilsTarget tissuesHealthy tissueGenotoxic injuryEarly ageMultiple tissuesTissueTissue environmentPhysiological demandsInflammationHematopoietic homeostasisCXCR4LungNon-canonical functionsInjuryCancerInfectionLeukocytes
2024
Neutrophils in Physiology and Pathology
Aroca-Crevillén A, Vicanolo T, Ovadia S, Hidalgo A. Neutrophils in Physiology and Pathology. Annual Review Of Pathology Mechanisms Of Disease 2024, 19: 227-259. PMID: 38265879, PMCID: PMC11060889, DOI: 10.1146/annurev-pathmechdis-051222-015009.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCardiovascular InfectionsHealth PromotionHumansNeoplasmsNeutrophilsDeterministic reprogramming of neutrophils within tumors
Ng M, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo G, Yang K, Zhang Y, Jin J, Liong K, Wu D, He R, Liu D, Teh Y, Bleriot C, Caronni N, Liu Z, Duan K, Narang V, Ballesteros I, Moalli F, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y, Tey H, Chong S, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng L. Deterministic reprogramming of neutrophils within tumors. Science 2024, 383: eadf6493. PMID: 38207030, PMCID: PMC11087151, DOI: 10.1126/science.adf6493.Peer-Reviewed Original Research
2022
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S. Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease. Immunity 2022, 55: 2285-2299.e7. PMID: 36272416, PMCID: PMC9767676, DOI: 10.1016/j.immuni.2022.10.001.Peer-Reviewed Original Research
2020
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
Adrover JM, Aroca-Crevillén A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzón-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoaín I, Torres A, Ruiz-Cabello J, Vázquez J, Hidalgo A. Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation. Nature Immunology 2020, 21: 135-144. PMID: 31932813, PMCID: PMC7223223, DOI: 10.1038/s41590-019-0571-2.Peer-Reviewed Original ResearchConceptsMagnitude of inflammationNeutrophil extracellular trapsNeutrophil proteomeGranule contentsInflammatory injuryRespiratory distressPneumonia patientsExtracellular trapsCell-intrinsic programsProgressive lossHuman neutrophilsNET formationProtein storesNeutrophilsInflammationLungAntimicrobial functionMouse mutantsCircadian cyclePatientsInjuryTime of dayArmamentariumIncidenceSeverity
2014
Neutrophils scan for activated platelets to initiate inflammation
Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nácher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A. Neutrophils scan for activated platelets to initiate inflammation. Science 2014, 346: 1234-1238. PMID: 25477463, PMCID: PMC4280847, DOI: 10.1126/science.1256478.Peer-Reviewed Original Research
2013
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance. Cell 2013, 153: 1025-1035. PMID: 23706740, PMCID: PMC4128329, DOI: 10.1016/j.cell.2013.04.040.Peer-Reviewed Original ResearchConceptsBone marrowFunction of neutrophilsNeutrophil clearanceHomeostatic clearanceHematopoietic nicheNeutrophil eliminationHomeostatic signalsAged neutrophilsNeutrophilsRhythmic modulationMarrowCircadian eventsNuclear receptorsHematopoietic progenitorsClearanceInflammationLeukocytesMiceMacrophagesCirculationReceptors
2009
Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY, Frenette PS. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nature Medicine 2009, 15: 384-391. PMID: 19305412, PMCID: PMC2772164, DOI: 10.1038/nm.1939.Peer-Reviewed Original Research
2007
Complete Identification of E-Selectin Ligands on Neutrophils Reveals Distinct Functions of PSGL-1, ESL-1, and CD44
Hidalgo A, Peired AJ, Wild M, Vestweber D, Frenette PS. Complete Identification of E-Selectin Ligands on Neutrophils Reveals Distinct Functions of PSGL-1, ESL-1, and CD44. Immunity 2007, 26: 477-489. PMID: 17442598, PMCID: PMC4080624, DOI: 10.1016/j.immuni.2007.03.011.Peer-Reviewed Original Research
2005
CD44 is a physiological E-selectin ligand on neutrophils
Katayama Y, Hidalgo A, Chang J, Peired A, Frenette PS. CD44 is a physiological E-selectin ligand on neutrophils. Journal Of Experimental Medicine 2005, 201: 1183-1189. PMID: 15824084, PMCID: PMC2213157, DOI: 10.1084/jem.20042014.Peer-Reviewed Original ResearchConceptsCell-specific posttranslational modificationsLeukocyte adhesion deficiency type IIPosttranslational modificationsPotential new targetsE-selectinInnate immune responseBroader roleEndothelial cell lineThioglycollate-induced peritonitisP-selectin glycoprotein ligand-1Cell linesNew targetsE-selectin ligandsAdhesion moleculesStaphylococcal enterotoxin ANeutrophil extravasationImmune responseSelectin familyCD44Bone marrowHuman PMNPMN bindInfectious sitesSelectin ligandsSkin pouch