Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Weinberger T, Denise M, Joppich M, Fischer M, Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu H, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Perdiguero E, Schulz C. Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia. ELife 2024, 12: rp89377. PMID: 38775664, PMCID: PMC11111219, DOI: 10.7554/elife.89377.Peer-Reviewed Original ResearchConceptsInfarct sizeCardiac remodelingI/R injuryMacrophage populationsDeterioration of cardiac functionRecruitment of monocyte-derived macrophagesIschemia/reperfusion (I/R) injuryAntigen-presenting macrophagesImmune cell crosstalkSubsets of macrophagesIncreased infarct sizeMonocyte-derived macrophagesResponse to injuryInfluence infarct sizeContext of myocardial infarctionCSF1R inhibitionCardiac healingCardiac macrophagesCardiac functionCell crosstalkAdverse remodelingResident macrophagesTissue macrophagesMacrophage lineageMyocardial ischemia