Featured Publications
Strategies of neutrophil diversification
Palomino-Segura M, Sicilia J, Ballesteros I, Hidalgo A. Strategies of neutrophil diversification. Nature Immunology 2023, 24: 575-584. PMID: 36959290, PMCID: PMC10139675, DOI: 10.1038/s41590-023-01452-x.Peer-Reviewed Original Research
2020
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
Adrover JM, Aroca-Crevillén A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzón-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoaín I, Torres A, Ruiz-Cabello J, Vázquez J, Hidalgo A. Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation. Nature Immunology 2020, 21: 135-144. PMID: 31932813, PMCID: PMC7223223, DOI: 10.1038/s41590-019-0571-2.Peer-Reviewed Original ResearchConceptsMagnitude of inflammationNeutrophil extracellular trapsNeutrophil proteomeGranule contentsInflammatory injuryRespiratory distressPneumonia patientsExtracellular trapsCell-intrinsic programsProgressive lossHuman neutrophilsNET formationProtein storesNeutrophilsInflammationLungAntimicrobial functionMouse mutantsCircadian cyclePatientsInjuryTime of dayArmamentariumIncidenceSeverity