2024
Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury
Ruscitti C, Abinet J, Maréchal P, Meunier M, de Meeûs C, Vanneste D, Janssen P, Dourcy M, Thiry M, Bureau F, Schneider C, Machiels B, Hidalgo A, Ginhoux F, Dewals B, Guiot J, Schleich F, Garigliany M, Bellahcène A, Radermecker C, Marichal T. Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology 2024, 9: eado1227-eado1227. PMID: 39093958, PMCID: PMC7616420, DOI: 10.1126/sciimmunol.ado1227.Peer-Reviewed Original ResearchConceptsLung injuryAlveolar regenerationGranulocyte-macrophage colony-stimulating factorColony-stimulating factorType 2 epithelial cellsAlveolar type 2 epithelial cellsPopulation of macrophagesModels of injuryImmune cellsSuspected pneumoniaA virusAlveolar damageEpithelial regenerationInterleukin-4Lung damageMacrophage subsetsReceptor signalingLungPerilesional areaRepair responseMacrophagesTherapeutic targetInjuryCellsAirborne pathogens
2023
The local microenvironment drives activation of neutrophils in human brain tumors
Maas R, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado Á, Marie D, Lilja J, Marcone R, Calvo G, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger A, Brouland J, Daniel R, Hegi M, Joyce J. The local microenvironment drives activation of neutrophils in human brain tumors. Cell 2023, 186: 4546-4566.e27. PMID: 37769657, DOI: 10.1016/j.cell.2023.08.043.Peer-Reviewed Original ResearchTumor-associated neutrophilsHuman brain tumorsBrain tumorsTumor necrosis factor alphaDistinct inflammatory signatureOverall immune suppressionBrain metastasis patientsPro-inflammatory mediatorsSoluble inflammatory mediatorsAbundant immune cellsNecrosis factor alphaActivation of neutrophilsTumor-associated macrophagesPro-angiogenic capacityBrain metastasesInflammatory signatureMetastasis patientsInflammatory mediatorsNeutrophil phenotypeImmune suppressionPeripheral bloodBlood neutrophilsDifferent cancer typesImmune cellsBrain microenvironment