Featured Publications
The circadian neutrophil, inside-out
Ovadia S, Özcan A, Hidalgo A. The circadian neutrophil, inside-out. Journal Of Leukocyte Biology 2023, 113: 555-566. PMID: 36999376, PMCID: PMC10583762, DOI: 10.1093/jleuko/qiad038.Peer-Reviewed Original Research
2024
Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury
Ruscitti C, Abinet J, Maréchal P, Meunier M, de Meeûs C, Vanneste D, Janssen P, Dourcy M, Thiry M, Bureau F, Schneider C, Machiels B, Hidalgo A, Ginhoux F, Dewals B, Guiot J, Schleich F, Garigliany M, Bellahcène A, Radermecker C, Marichal T. Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology 2024, 9: eado1227-eado1227. PMID: 39093958, PMCID: PMC7616420, DOI: 10.1126/sciimmunol.ado1227.Peer-Reviewed Original ResearchConceptsLung injuryAlveolar regenerationGranulocyte-macrophage colony-stimulating factorColony-stimulating factorType 2 epithelial cellsAlveolar type 2 epithelial cellsPopulation of macrophagesModels of injuryImmune cellsSuspected pneumoniaA virusAlveolar damageEpithelial regenerationInterleukin-4Lung damageMacrophage subsetsReceptor signalingLungPerilesional areaRepair responseMacrophagesTherapeutic targetInjuryCellsAirborne pathogensA concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin
Klemt I, Reshetnikov V, Dutta S, Bila G, Bilyy R, Cuartero I, Hidalgo A, Wünsche A, Böhm M, Wondrak M, Kunz-Schughart L, Tietze R, Beierlein F, Imhof P, Gensberger-Reigl S, Pischetsrieder M, Körber M, Jost T, Mokhir A. A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin. RSC Medicinal Chemistry 2024, 15: 1189-1197. PMID: 38665843, PMCID: PMC11042170, DOI: 10.1039/d3md00609c.Peer-Reviewed Original Research
2009
Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY, Frenette PS. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nature Medicine 2009, 15: 384-391. PMID: 19305412, PMCID: PMC2772164, DOI: 10.1038/nm.1939.Peer-Reviewed Original Research