2016
Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell Behavior
Kshitiz, Afzal J, Chang H, Goyal R, Levchenko A. Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell Behavior. Current Stem Cell Reports 2016, 2: 62-72. DOI: 10.1007/s40778-016-0033-9.Peer-Reviewed Original ResearchStem cell biologyStem cell behaviorMechanical cuesCell biologyCell behaviorFundamental stem cell biologyNovel bioengineering toolsIntracellular signal transductionStem cell phenotypeExtracellular stimuliSignal transductionAdult tissuesInstructive cuesBioengineering toolsFuture therapeutic applicationsExtracellular matrixStem cellsComplex milieuCell phenotypeCulture conditionsRegenerative medicineMechanotransductionBiologyTopographical architectureTherapeutic applications
2006
Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications
Cheong R, Levchenko A. Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications. 2006 DOI: 10.1002/3527600906.mcb.200500006.Peer-Reviewed Original ResearchTranscription factor subunitNF-κBTranscription factor NFPosttranslation modificationsSignal transductionTranscription factorsFactor subunitTarget genesCombinatorial specificityRel familyStress responseGreat therapeutic interestFactor NFIκB kinaseNF-κB activityMost cellsNumerous mechanismsSubunitsCentral roleTherapeutic interestInhibitorsTransductionKinaseGenesCytoplasm
2004
The Systems Biology of Glycosylation
Murrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation. ChemBioChem 2004, 5: 1334-1347. PMID: 15457533, DOI: 10.1002/cbic.200400143.Peer-Reviewed Original ResearchConceptsSystems biologyRegulation of differentiationRegulation of glycosylationEukaryotic cellsBiochemical systems analysisCell regulation processesCell decisionsSignal transductionGlycosylationBiologyRegulation processesRegulationTransductionApoptosisDifferentiationProfound influenceCellsNovel research methodology
2000
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
Levchenko A, Bruck J, Sternberg P. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 5818-5823. PMID: 10823939, PMCID: PMC18517, DOI: 10.1073/pnas.97.11.5818.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseScaffold proteinProtein kinaseSpecific cellular contextDifferent subcellular compartmentsDetailed biochemical modelCellular contextSignal transductionSubcellular compartmentsScaffold concentrationsScaffold levelMultimolecular complexesFull activationGeneric scaffoldKinaseProteinBiochemical modelPathwaySignal propagationTransductionComplexesQuantitative computer modelCrosstalkCompartmentsActivation