2005
Dynamic Properties of Network Motifs Contribute to Biological Network Organization
Prill R, Iglesias P, Levchenko A. Dynamic Properties of Network Motifs Contribute to Biological Network Organization. PLOS Biology 2005, 3: e343. PMID: 16187794, PMCID: PMC1239925, DOI: 10.1371/journal.pbio.0030343.Peer-Reviewed Original ResearchConceptsBiological networksRobust dynamical stabilityLarge-scale dynamic systemsNon-random networksBiological network organizationDeep interplayDynamical stabilityDynamical propertiesDynamic systemsSmall perturbationsExhaustive computational analysisSystem dynamicsDynamical implicationsSmaller subnetworksNon-random structureNetwork motifsNetwork structureDynamic propertiesNetworkComputational analysisPropertiesPerturbationsRobustnessDynamicsStability
2003
Dynamical and integrative cell signaling: challenges for the new biology
Levchenko A. Dynamical and integrative cell signaling: challenges for the new biology. Biotechnology And Bioengineering 2003, 84: 773-782. PMID: 14708118, DOI: 10.1002/bit.10854.Peer-Reviewed Original ResearchConceptsProtein-centric approachSystems biology approachSignal transduction pathwaysNeural networkHigh-fidelity informationCareful experimental analysisBiology approachStatic worldTransduction pathwaysCell signalingPostgenomic eraHigh-throughput analysisIntracellular networksNetworkComplex networksNew biologyVolatile environmentBiological researchNotion of concentrationStructural viewBiochemical reactionsDynamical viewExperimental analysisPathwayPrimary determinant