2020
CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMA
Schiapparelli P, Meade P, Miranda-Herrera P, Bechtle A, Issacs F, Levchenko A, Rinehart J, Quinones-Hinojosa A. CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMA. Neuro-Oncology 2020, 22: ii29-ii29. PMCID: PMC7650317, DOI: 10.1093/neuonc/noaa215.120.Peer-Reviewed Original ResearchOxidative stress-responsive kinase 1Small molecule inhibitorsGBM cellsMolecule inhibitorsAggressive primary brain tumorCell migrationComplete surgical resectionMaximal safe resectionPrimary brain tumorsAdjacent brain parenchymaCell proliferationOrthotopic murine modelPatient-derived GBM cell linesDose-dependent reductionImportant therapeutic componentGBM cell linesCell cycle analysisGBM cell migrationSurgical resectionSafe resectionBrain parenchymaCell infiltrationCell cycle arrestMurine modelRadiation therapy
2014
TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASION
Abbadi S, Rodarte J, Abutaleb A, Lavell E, Smith C, Ruff W, Schiller J, Olivi A, Levchenko A, Guerrero-Cazares H, Quinones-Hinojosa A. TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASION. Neuro-Oncology 2014, 16: v213-v213. PMCID: PMC4218619, DOI: 10.1093/neuonc/nou278.1.Peer-Reviewed Original ResearchBrain tumor initiating cellsGlycolytic inhibitionGlioblastoma cell invasionSuch reprogrammingKnockdown cellsMetabolic reprogrammingTumor initiating cellsKey enzymeGlycogen synthaseCell survivalAggressive primary brain cancerCell invasionComplete rescueFunctional consequencesPotential therapeutic targetPrimary brain cancerGBM cellsWild-type miceG6PCReprogrammingInitiating cellsGlycogen accumulationGlycogen phosphorylaseMalignant progressionKnockdown