2020
Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans
Mathias S, Knowles E, Mollon J, Rodrigue A, Koenis M, Alexander-Bloch A, Winkler A, Olvera R, Duggirala R, Göring H, Curran J, Fox P, Almasy L, Blangero J, Glahn D. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cerebral Cortex 2020, 30: 3439-3450. PMID: 32037459, PMCID: PMC7233007, DOI: 10.1093/cercor/bhz319.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCerebral CortexCognitionFemaleHumansIntelligenceMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsYoung AdultConceptsGeneral cognitive abilityCognitive abilitiesLocal gyrificationSuperior cognitive abilitiesCortical surface pointsNeurobiology of intelligenceCognitive testsNeuroimaging studiesNeuroanatomical variablesStructural brain imagesMinimal relationshipCortical regionsEffect sizeGyrificationPrevious studiesAbilityNeurobiologyBrain imagesIntelligenceRelationshipHumansIndividualsPotential issuesImplicationsProfound implications
2015
Fast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimation
2014
Discovering Schizophrenia Endophenotypes in Randomly Ascertained Pedigrees
Glahn DC, Williams JT, McKay DR, Knowles EE, Sprooten E, Mathias SR, Curran JE, Kent JW, Carless MA, Göring HH, Dyer TD, Woolsey MD, Winkler AM, Olvera RL, Kochunov P, Fox PT, Duggirala R, Almasy L, Blangero J. Discovering Schizophrenia Endophenotypes in Randomly Ascertained Pedigrees. Biological Psychiatry 2014, 77: 75-83. PMID: 25168609, PMCID: PMC4261014, DOI: 10.1016/j.biopsych.2014.06.027.Peer-Reviewed Original Research
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insightsImpact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
Carless MA, Glahn DC, Johnson MP, Curran JE, Bozaoglu K, Dyer TD, Winkler AM, Cole SA, Almasy L, MacCluer JW, Duggirala R, Moses EK, Göring HH, Blangero J. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Molecular Psychiatry 2011, 16: 1096-1104. PMID: 21483430, PMCID: PMC3135724, DOI: 10.1038/mp.2011.37.Peer-Reviewed Original ResearchCerebral CortexCognitionDepressionGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyGenotypeHumansInterview, PsychologicalLymphocytesMemory, Short-TermMexican AmericansMicrosatellite RepeatsNerve Tissue ProteinsNeuropsychological TestsPanic DisorderPhenotypePolymorphism, GeneticPolymorphism, Single NucleotideRNA, MessengerSampling StudiesTexasTranscription, Genetic
2010
A Multimodal Assessment of the Genetic Control over Working Memory
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC. A Multimodal Assessment of the Genetic Control over Working Memory. Journal Of Neuroscience 2010, 30: 8197-8202. PMID: 20554870, PMCID: PMC2894480, DOI: 10.1523/jneurosci.0359-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnisotropyBrainBrain MappingDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMexican AmericansMiddle AgedNerve Fibers, MyelinatedNeural PathwaysNeuropsychological TestsOxygenPedigreeYoung AdultConceptsMemory performanceComplex cognitive functionsHigher-level processesGray matter densityWorking memoryCognitive measuresResponse taskStructural magnetic resonanceGeneral intelligenceSuperior longitudinal fasciculusHuman participantsWhite matter tractsCognitive functionCognitive deficitsOnly performanceMultimodal assessmentBrain regionsMemoryCommon genetic factorsLongitudinal fasciculusMajor white matter tractsLevel processesMeasuresGray matter regionsCore component