2015
The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects
Kochunov P, Thompson P, Winkler A, Morrissey M, Fu M, Coyle T, Du X, Muellerklein F, Savransky A, Gaudiot C, Sampath H, Eskandar G, Jahanshad N, Patel B, Rowland L, Nichols T, O'Connell J, Shuldiner A, Mitchell B, Hong L. The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects. NeuroImage 2015, 125: 189-197. PMID: 26499807, PMCID: PMC4691385, DOI: 10.1016/j.neuroimage.2015.10.050.Peer-Reviewed Original Research
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insightsImpact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
Carless MA, Glahn DC, Johnson MP, Curran JE, Bozaoglu K, Dyer TD, Winkler AM, Cole SA, Almasy L, MacCluer JW, Duggirala R, Moses EK, Göring HH, Blangero J. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Molecular Psychiatry 2011, 16: 1096-1104. PMID: 21483430, PMCID: PMC3135724, DOI: 10.1038/mp.2011.37.Peer-Reviewed Original ResearchCerebral CortexCognitionDepressionGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyGenotypeHumansInterview, PsychologicalLymphocytesMemory, Short-TermMexican AmericansMicrosatellite RepeatsNerve Tissue ProteinsNeuropsychological TestsPanic DisorderPhenotypePolymorphism, GeneticPolymorphism, Single NucleotideRNA, MessengerSampling StudiesTexasTranscription, Genetic
2010
Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure
Kochunov P, Glahn D, Lancaster J, Winkler A, Kent JW, Olvera RL, Cole SA, Dyer TD, Almasy L, Duggirala R, Fox PT, Blangero J. Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure. Stroke 2010, 41: 2137-2142. PMID: 20724716, PMCID: PMC3084627, DOI: 10.1161/strokeaha.110.590943.Peer-Reviewed Original Research