2024
The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease
Manuello J, Min J, McCarthy P, Alfaro-Almagro F, Lee S, Smith S, Elliott L, Winkler A, Douaud G. The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease. Nature Communications 2024, 15: 2576. PMID: 38538590, PMCID: PMC10973379, DOI: 10.1038/s41467-024-46344-2.Peer-Reviewed Original ResearchConceptsModifiable risk factorsRisk factorsBrain networksUK Biobank participantsTraffic-related air pollutionAlcohol intake frequencyBrain regionsGenome-wide associationBiobank participantsHigher-order brain regionsIntake frequencyXg blood groupEffects of ageCardiovascular deathGenetic influencesUnique contributionsNitrogen dioxideSchizophreniaBrainAgeAir pollutionAlzheimer's diseaseParkinson's diseaseSexAssociation
2011
Genetic Architecture of Declarative Memory
Bearden CE, Karlsgodt KH, Bachman P, van Erp TG, Winkler AM, Glahn DC. Genetic Architecture of Declarative Memory. The Neuroscientist 2011, 18: 516-532. PMID: 21832260, PMCID: PMC3545476, DOI: 10.1177/1073858411415113.Peer-Reviewed Original ResearchConceptsGenetic architectureIndependent inheritanceGenetic basisMolecular basisSingle gene disordersMolecular mechanismsGeneralist genesMemory functionHuman memory functionLong-term memoryDistinct aspectsGenesDeclarative memoryCognitive domainsMemory abilityDistinct subcomponentsInheritanceMemoryFunctionIndividual variabilityDomainImportant informationEvidence