2015
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task
Acheson A, Tagamets M, Winkler A, Rowland L, Mathias C, Wright S, Hong L, Kochunov P, Dougherty D. Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task. Brain And Behavior 2015, 5: e00352. PMID: 26221573, PMCID: PMC4511289, DOI: 10.1002/brb3.352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAspartic AcidBrain MappingChildCorpus StriatumExecutive FunctionFamilyFemaleGenetic Predisposition to DiseaseHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMotor CortexNeural PathwaysProton Magnetic Resonance SpectroscopyPsychomotor PerformanceSignal Processing, Computer-AssistedSubstance-Related DisordersWhite MatterConceptsSupplementary motor areaSubstance use disordersWhite matter integrityFamily historyFrontal white matter integrityStriatal activityDorsal striatumFrontal cortical activityCortical activitySMA activityFrontal cortical projectionsDrug use disordersDorsal striatal activitySuch family historyDorsal striatum activityCortical projectionsMotor areaElevated riskOngoing longitudinal studyUse disordersWhite matterDownstream projectionsGo/Fast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimation
2014
Discovering Schizophrenia Endophenotypes in Randomly Ascertained Pedigrees
Glahn DC, Williams JT, McKay DR, Knowles EE, Sprooten E, Mathias SR, Curran JE, Kent JW, Carless MA, Göring HH, Dyer TD, Woolsey MD, Winkler AM, Olvera RL, Kochunov P, Fox PT, Duggirala R, Almasy L, Blangero J. Discovering Schizophrenia Endophenotypes in Randomly Ascertained Pedigrees. Biological Psychiatry 2014, 77: 75-83. PMID: 25168609, PMCID: PMC4261014, DOI: 10.1016/j.biopsych.2014.06.027.Peer-Reviewed Original Research
2013
Influence of age, sex and genetic factors on the human brain
McKay DR, Knowles EE, Winkler AA, Sprooten E, Kochunov P, Olvera RL, Curran JE, Kent JW, Carless MA, Göring HH, Dyer TD, Duggirala R, Almasy L, Fox PT, Blangero J, Glahn DC. Influence of age, sex and genetic factors on the human brain. Brain Imaging And Behavior 2013, 8: 143-152. PMID: 24297733, PMCID: PMC4011973, DOI: 10.1007/s11682-013-9277-5.Peer-Reviewed Original Research