2023
Structural and functional asymmetry of the neonatal cerebral cortex
Williams L, Fitzgibbon S, Bozek J, Winkler A, Dimitrova R, Poppe T, Schuh A, Makropoulos A, Cupitt J, O’Muircheartaigh J, Duff E, Cordero-Grande L, Price A, Hajnal J, Rueckert D, Smith S, Edwards A, Robinson E. Structural and functional asymmetry of the neonatal cerebral cortex. Nature Human Behaviour 2023, 7: 942-955. PMID: 36928781, DOI: 10.1038/s41562-023-01542-8.Peer-Reviewed Original ResearchConceptsCortical asymmetryHealthy term-born neonatesNeonatal cerebral cortexTerm-born neonatesTerm-equivalent ageHealthy young adultsHuman Connectome ProjectPreterm birthPreterm neonatesNeonatal cortexCerebral cortexTerm cohortFunctional magnetic resonance imagesMagnetic resonance imagesConnectome ProjectBrain asymmetryYoung adultsSignificant differencesNeonatesResonance imagesFunctional asymmetryCortexBirthBiological sexCohort
2020
Mega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group
Zugman A, Harrewijn A, Cardinale E, Zwiebel H, Freitag G, Werwath K, Bas‐Hoogendam J, Groenewold N, Aghajani M, Hilbert K, Cardoner N, Porta‐Casteràs D, Gosnell S, Salas R, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo‐Baum K, Thomopoulos S, Grabe H, Van der Auwera S, Wittfeld K, Nielsen J, Buckner R, Smoller J, Mwangi B, Soares J, Wu M, Zunta‐Soares G, Jackowski A, Pan P, Salum G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza A, Filippi C, Leibenluft E, Alberton B, Balderston N, Ernst M, Grillon C, Mujica‐Parodi L, van Nieuwenhuizen H, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Yu Q, Sylvester C, Veltman D, Lueken U, Van der Wee N, Stein D, Jahanshad N, Thompson P, Pine D, Winkler A. Mega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Human Brain Mapping 2020, 43: 255-277. PMID: 32596977, PMCID: PMC8675407, DOI: 10.1002/hbm.25096.Peer-Reviewed Original ResearchMinimal Relationship between Local Gyrification and General Cognitive Ability in Humans
Mathias S, Knowles E, Mollon J, Rodrigue A, Koenis M, Alexander-Bloch A, Winkler A, Olvera R, Duggirala R, Göring H, Curran J, Fox P, Almasy L, Blangero J, Glahn D. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cerebral Cortex 2020, 30: 3439-3450. PMID: 32037459, PMCID: PMC7233007, DOI: 10.1093/cercor/bhz319.Peer-Reviewed Original ResearchConceptsGeneral cognitive abilityCognitive abilitiesLocal gyrificationSuperior cognitive abilitiesCortical surface pointsNeurobiology of intelligenceCognitive testsNeuroimaging studiesNeuroanatomical variablesStructural brain imagesMinimal relationshipCortical regionsEffect sizeGyrificationPrevious studiesAbilityNeurobiologyBrain imagesIntelligenceRelationshipHumansIndividualsPotential issuesImplicationsProfound implications
2019
Combining fMRI during resting state and an attention bias task in children
Harrewijn A, Abend R, Linke J, Brotman M, Fox N, Leibenluft E, Winkler A, Pine D. Combining fMRI during resting state and an attention bias task in children. NeuroImage 2019, 205: 116301. PMID: 31639510, PMCID: PMC6911838, DOI: 10.1016/j.neuroimage.2019.116301.Peer-Reviewed Original ResearchConceptsDot-probe taskAttention bias taskFunctional connectivityThreat biasBias taskCognitive tasksDifferent attentional processesReconfiguration efficiencyTask-based fMRI dataAttentional processesAttention taskSocial reticenceTask performanceAttention stateAnxiety symptomsFMRI dataPattern of modulationPrior researchTaskIQFMRICurrent studyChildrenFunctional hierarchyNetwork changesSchizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits
Ji JL, Diehl C, Schleifer C, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA, Hill SK, Pearlson G, Yang G, Creatura G, Krystal JH, Repovs G, Murray J, Winkler A, Anticevic A. Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits. Cerebral Cortex 2019, 29: 4463-4487. PMID: 31157363, PMCID: PMC6917525, DOI: 10.1093/cercor/bhy306.Peer-Reviewed Original ResearchConceptsBrain-wide alterationsResting-state functional magnetic resonanceSensory-motor cortexFunctional magnetic resonanceNeural dysconnectivityPolysynaptic connectionsCortico-striatoFunctional disturbancesChronic patientsAssociation cortexFocal disruptionNeural effectsCerebellar circuitsPatientsDysconnectivityStriatal componentsSchizophreniaCortexSpecific alterationsHallmark featureCognitive performanceAlterationsFunctional pathwaysQuestion accountsMagnetic resonance
2016
Non‐parametric combination and related permutation tests for neuroimaging
Winkler AM, Webster MA, Brooks JC, Tracey I, Smith SM, Nichols TE. Non‐parametric combination and related permutation tests for neuroimaging. Human Brain Mapping 2016, 37: 1486-1511. PMID: 26848101, PMCID: PMC4783210, DOI: 10.1002/hbm.23115.Peer-Reviewed Original Research
2015
Multi-level block permutation
Winkler AM, Webster MA, Vidaurre D, Nichols TE, Smith SM. Multi-level block permutation. NeuroImage 2015, 123: 253-268. PMID: 26074200, PMCID: PMC4644991, DOI: 10.1016/j.neuroimage.2015.05.092.Peer-Reviewed Original Research
2013
Identification of Pleiotropic Genetic Effects on Obesity and Brain Anatomy
Curran JE, McKay DR, Winkler AM, Olvera RL, Carless MA, Dyer TD, Kent JW, Kochunov P, Sprooten E, Knowles EE, Comuzzie AG, Fox PT, Almasy L, Duggirala R, Blangero J, Glahn DC. Identification of Pleiotropic Genetic Effects on Obesity and Brain Anatomy. Human Heredity 2013, 75: 136-143. PMID: 24081229, PMCID: PMC3889074, DOI: 10.1159/000353953.Peer-Reviewed Original ResearchConceptsBody mass indexBrain anatomyEnergy homeostasisDevelopment of obesityLeptin-induced signalingCortical surface areaMass indexGut signalsChronic diseasesGlobal burdenObesitySubcortical volumesBiologic underpinningsReward circuitrySupramarginal gyrusGenetic factorsMexican-American individualsCommon genetic mechanismPleiotropic genetic effectsAnatomyBrainNeuroanatomical variationAmerican individualsCurrent knowledgePleiotropic effectsTranscriptomics of cortical gray matter thickness decline during normal aging
Kochunov P, Charlesworth J, Winkler A, Hong LE, Nichols TE, Curran JE, Sprooten E, Jahanshad N, Thompson PM, Johnson MP, Kent JW, Landman BA, Mitchell B, Cole SA, Dyer TD, Moses EK, Goring HH, Almasy L, Duggirala R, Olvera RL, Glahn DC, Blangero J. Transcriptomics of cortical gray matter thickness decline during normal aging. NeuroImage 2013, 82: 273-283. PMID: 23707588, PMCID: PMC3759649, DOI: 10.1016/j.neuroimage.2013.05.066.Peer-Reviewed Original ResearchConceptsPathway enrichment analysisTranscriptome dataInnate immune pathwaysEnrichment analysisCellular proliferationInnate immune response pathwaysImmune pathwaysImmune response pathwaysResponse pathwaysFunctional categoriesPathway enrichmentTranscriptional activityGenesExpression activityTranscriptsHigh-resolution T1-weighted MRINormal cerebral agingCommunity-dwelling membersPathwaySignificance thresholdRegenerative capacityT1-weighted MRIDifferentiationCerebral agingViral infection
2012
Measuring and comparing brain cortical surface area and other areal quantities
Winkler AM, Sabuncu MR, Yeo BT, Fischl B, Greve DN, Kochunov P, Nichols TE, Blangero J, Glahn DC. Measuring and comparing brain cortical surface area and other areal quantities. NeuroImage 2012, 61: 1428-1443. PMID: 22446492, PMCID: PMC3641659, DOI: 10.1016/j.neuroimage.2012.03.026.Peer-Reviewed Original Research
2011
Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
Carless MA, Glahn DC, Johnson MP, Curran JE, Bozaoglu K, Dyer TD, Winkler AM, Cole SA, Almasy L, MacCluer JW, Duggirala R, Moses EK, Göring HH, Blangero J. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Molecular Psychiatry 2011, 16: 1096-1104. PMID: 21483430, PMCID: PMC3135724, DOI: 10.1038/mp.2011.37.Peer-Reviewed Original ResearchCerebral CortexCognitionDepressionGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyGenotypeHumansInterview, PsychologicalLymphocytesMemory, Short-TermMexican AmericansMicrosatellite RepeatsNerve Tissue ProteinsNeuropsychological TestsPanic DisorderPhenotypePolymorphism, GeneticPolymorphism, Single NucleotideRNA, MessengerSampling StudiesTexasTranscription, Genetic
2010
Genetics of microstructure of cerebral white matter using diffusion tensor imaging
Kochunov P, Glahn DC, Lancaster JL, Winkler AM, Smith S, Thompson PM, Almasy L, Duggirala R, Fox PT, Blangero J. Genetics of microstructure of cerebral white matter using diffusion tensor imaging. NeuroImage 2010, 53: 1109-1116. PMID: 20117221, PMCID: PMC2888778, DOI: 10.1016/j.neuroimage.2010.01.078.Peer-Reviewed Original Research