An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue
Tackley G, Kong Y, Minne R, Messina S, Winkler A, Cavey A, Everett R, DeLuca G, Weir A, Craner M, Tracey I, Palace J, Stagg C, Emir U. An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue. NeuroImage 2021, 238: 118225. PMID: 34062267, PMCID: PMC7611458, DOI: 10.1016/j.neuroimage.2021.118225.Peer-Reviewed Original ResearchMeSH KeywordsAdultAquaporin 4Aspartic AcidAutoantibodiesAutoantigensBrain ChemistryFemaleGliosisGlutamatesHumansInositolMagnetic Resonance SpectroscopyMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingNerve Tissue ProteinsNeuromyelitis OpticaYoung AdultConceptsTotal N-acetylaspartateMultiple sclerosisN-acetylaspartateBrain lesionsPositive neuromyelitis optica spectrum disorderWhite matterNeuromyelitis optica spectrum disorderOptica spectrum disorderChronic multiple sclerosisPost-hoc testingBrain white matterDisease groupMRS methodologyMRS profilesMRS studiesReciprocal findingsNon-invasive quantificationBrain tissueLesionsMagnetic resonance spectroscopyMyo-inositolDistinct diseasesNormal tissuesCNS moleculesIn-Vivo