2023
Structural and functional asymmetry of the neonatal cerebral cortex
Williams L, Fitzgibbon S, Bozek J, Winkler A, Dimitrova R, Poppe T, Schuh A, Makropoulos A, Cupitt J, O’Muircheartaigh J, Duff E, Cordero-Grande L, Price A, Hajnal J, Rueckert D, Smith S, Edwards A, Robinson E. Structural and functional asymmetry of the neonatal cerebral cortex. Nature Human Behaviour 2023, 7: 942-955. PMID: 36928781, DOI: 10.1038/s41562-023-01542-8.Peer-Reviewed Original ResearchConceptsCortical asymmetryHealthy term-born neonatesNeonatal cerebral cortexTerm-born neonatesTerm-equivalent ageHealthy young adultsHuman Connectome ProjectPreterm birthPreterm neonatesNeonatal cortexCerebral cortexTerm cohortFunctional magnetic resonance imagesMagnetic resonance imagesConnectome ProjectBrain asymmetryYoung adultsSignificant differencesNeonatesResonance imagesFunctional asymmetryCortexBirthBiological sexCohort
2017
Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity
van der Meer D, Hoekstra P, van Rooij D, Winkler A, van Ewijk H, Heslenfeld D, Oosterlaan J, Faraone S, Franke B, Buitelaar J, Hartman C. Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity. The World Journal Of Biological Psychiatry 2017, 19: 450-460. PMID: 28635543, PMCID: PMC5581282, DOI: 10.1080/15622975.2017.1287952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyAnxiety DisordersAttention Deficit Disorder with HyperactivityCerebellumChildCognitive DysfunctionCohort StudiesComorbidityCorpus StriatumFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMemory, Short-TermSeverity of Illness IndexThalamusYoung AdultConceptsAttention-deficit/hyperactivity disorderCo-occurring anxietyADHD severityNeural activityMemory taskAttention-deficit/hyperactivity disorder severityMemory-related brain activityPresence of ADHDVisuospatial Working Memory TaskWorking Memory TaskLevel of anxietyVSWM tasksMemory loadHyperactivity disorderTask accuracyPrevious theorisingAnxiety severityBrain activityNeurobiological heterogeneityDisorder severityAnxietyWorse performanceInformation gatingYoung adultsNeural pathways
2016
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia
Kochunov P, Ganjgahi H, Winkler A, Kelly S, Shukla D, Du X, Jahanshad N, Rowland L, Sampath H, Patel B, O'Donnell P, Xie Z, Paciga S, Schubert C, Chen J, Zhang G, Thompson P, Nichols T, Hong L. Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia. Human Brain Mapping 2016, 37: 4673-4688. PMID: 27477775, PMCID: PMC5118078, DOI: 10.1002/hbm.23336.Peer-Reviewed Original ResearchConceptsAge-related declineWhite matterSchizophrenia patientsFractional anisotropyFA valuesDiagnosis interactionFaster age-related declinePathophysiology of schizophreniaHum Brain MappEffect of diagnosisLower fractional anisotropyPatient-control differencesT Siemens MRI scannerBrain white matterClinical burdenRegional FA valuesPatientsAbnormal rateBrain connectivityTract developmentAdolescent maturationSpecific tractsRegional reductionDiagnosisSchizophrenia
2015
Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Kochunov P, Jahanshad N, Marcus D, Winkler A, Sprooten E, Nichols TE, Wright SN, Hong LE, Patel B, Behrens T, Jbabdi S, Andersson J, Lenglet C, Yacoub E, Moeller S, Auerbach E, Ugurbil K, Sotiropoulos SN, Brouwer RM, Landman B, Lemaitre H, Braber A, Zwiers MP, Ritchie S, van Hulzen K, Almasy L, Curran J, deZubicaray GI, Duggirala R, Fox P, Martin NG, McMahon KL, Mitchell B, Olvera RL, Peterson C, Starr J, Sussmann J, Wardlaw J, Wright M, Boomsma DI, Kahn R, de Geus EJ, Williamson DE, Hariri A, van 't Ent D, Bastin ME, McIntosh A, Deary IJ, pol H, Blangero J, Thompson PM, Glahn DC, Van Essen DC. Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage 2015, 111: 300-311. PMID: 25747917, PMCID: PMC4387079, DOI: 10.1016/j.neuroimage.2015.02.050.Peer-Reviewed Original Research
2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation
2009
Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume
Kochunov P, Glahn D, Winkler A, Duggirala R, Olvera RL, Cole S, Dyer TD, Almasy L, Fox PT, Blangero J. Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume. Stroke 2009, 40: 3685-3690. PMID: 19834011, PMCID: PMC2787844, DOI: 10.1161/strokeaha.109.565390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingBiomarkersBrain IschemiaCerebrospinal Fluid PressureCerebrumChromosome MappingCohort StudiesDisease ProgressionDNA Mutational AnalysisEpendymaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic TestingGenetic VariationHumansIntracranial HypertensionLeukoencephalopathiesMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNerve Fibers, MyelinatedYoung AdultConceptsArterial pulse pressurePulse pressureImportant neuroimaging markerFluid-attenuated inversion recovery imagesCommon risk factorsWhite matter volumeYears of ageInversion recovery imagesHealthy Mexican AmericansHWM volumeFamily Heart StudyRisk factorsCerebral volumeNeuroimaging markerHeart StudyMatter volumeWhite matterWhole brainPathophysiology studiesCerebral integritySan Antonio Family Heart StudyRecovery imagesMexican AmericansWhole-genome linkageGenome linkage