2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspects
2016
Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation
Klaassens B, Rombouts S, Winkler A, van Gorsel H, van der Grond J, van Gerven J. Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation. Human Brain Mapping 2016, 38: 308-325. PMID: 27622387, PMCID: PMC5215384, DOI: 10.1002/hbm.23362.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingCholinergic AgentsCholinesterase InhibitorsCitalopramCross-Over StudiesDouble-Blind MethodFemaleGalantamineHumansHydrocortisoneImage Processing, Computer-AssistedMaleModels, NeurologicalOxygenProlactinSelective Serotonin Reuptake InhibitorsSerotoninYoung AdultConceptsFunctional magnetic resonance imagingState functional magnetic resonance imagingSelf-referential mechanismCognitive performanceNeurotransmitter systemsVisual perceptionAcetylcholinesterase inhibitor galantamineSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramFunctional connectivityRs-fMRI scansSensorimotor networkReuptake inhibitor citalopramBrain neurotransmitter systemsFunctional networksPsychopharmacological researchHealthy young volunteersTime-specific effectsMagnetic resonance imagingGroup comparisonsState networksCrossover studySerotonergic stimulationAcute influenceHeart rate