2016
A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings
Sprooten E, Barrett J, McKay DR, Knowles EE, Mathias SR, Winkler AM, Brumbaugh MS, Landau S, Cyr L, Kochunov P, Glahn DC. A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings. Human Brain Mapping 2016, 37: 3474-3485. PMID: 27198848, PMCID: PMC5496097, DOI: 10.1002/hbm.23253.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBipolar DisorderBrainComorbidityDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedMaleNeural PathwaysOrgan SizePattern Recognition, AutomatedPsychiatric Status Rating ScalesSeverity of Illness IndexSiblingsYoung Adult
2013
Reduced White Matter Integrity in Sibling Pairs Discordant for Bipolar Disorder
Sprooten E, Brumbaugh MS, Knowles EE, McKay DR, Lewis J, Barrett J, Landau S, Cyr L, Kochunov P, Winkler AM, Pearlson GD, Glahn DC. Reduced White Matter Integrity in Sibling Pairs Discordant for Bipolar Disorder. American Journal Of Psychiatry 2013, 170: 1317-1325. PMID: 24185242, PMCID: PMC4119087, DOI: 10.1176/appi.ajp.2013.12111462.Peer-Reviewed Original ResearchAdultAnisotropyBipolar DisorderBrainCase-Control StudiesFemaleHumansMaleNeuroimagingPsychiatric Status Rating ScalesSiblings
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insights