2019
Accelerated estimation and permutation inference for ACE modeling
Chen X, Formisano E, Blokland G, Strike L, McMahon K, de Zubicaray G, Thompson P, Wright M, Winkler A, Ge T, Nichols T. Accelerated estimation and permutation inference for ACE modeling. Human Brain Mapping 2019, 40: 3488-3507. PMID: 31037793, PMCID: PMC6680147, DOI: 10.1002/hbm.24611.Peer-Reviewed Original ResearchConceptsPermutation inferenceIterative optimizationVariance component modelComputation timeComparable biasAccelerated estimationLinear modelSquared errorCluster sizeSpatial statisticsLinear regression modelsFalse positive riskInferenceHeritability estimationEstimationComponent modelModelWealth of toolsMemory datasetsOptimizationSimple methodSmall numberStatisticsACE modelPermutations
2016
A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings
Sprooten E, Barrett J, McKay DR, Knowles EE, Mathias SR, Winkler AM, Brumbaugh MS, Landau S, Cyr L, Kochunov P, Glahn DC. A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings. Human Brain Mapping 2016, 37: 3474-3485. PMID: 27198848, PMCID: PMC5496097, DOI: 10.1002/hbm.23253.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBipolar DisorderBrainComorbidityDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedMaleNeural PathwaysOrgan SizePattern Recognition, AutomatedPsychiatric Status Rating ScalesSeverity of Illness IndexSiblingsYoung Adult
2014
Permutation inference for the general linear model
Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. NeuroImage 2014, 92: 381-397. PMID: 24530839, PMCID: PMC4010955, DOI: 10.1016/j.neuroimage.2014.01.060.Peer-Reviewed Original ResearchConceptsPermutation inferenceNon-standard statisticsComplex general linear modelArbitrary experimental designsLinear modelPermutation methodOnly weak assumptionsGLM parametersWeak assumptionsSymmetric distributionExact controlGeneral linear modelNuisance variablesInferenceDetailed exampleComplete algorithmAlgorithmExperimental designIndependent dataNuisance effectsUseful caseGeneric frameworkModelStatisticsGLM