2023
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
Groenewold N, Bas-Hoogendam J, Amod A, Laansma M, Van Velzen L, Aghajani M, Hilbert K, Oh H, Salas R, Jackowski A, Pan P, Salum G, Blair J, Blair K, Hirsch J, Pantazatos S, Schneier F, Talati A, Roelofs K, Volman I, Blanco-Hinojo L, Cardoner N, Pujol J, Beesdo-Baum K, Ching C, Thomopoulos S, Jansen A, Kircher T, Krug A, Nenadić I, Stein F, Dannlowski U, Grotegerd D, Lemke H, Meinert S, Winter A, Erb M, Kreifelts B, Gong Q, Lui S, Zhu F, Mwangi B, Soares J, Wu M, Bayram A, Canli M, Tükel R, Westenberg P, Heeren A, Cremers H, Hofmann D, Straube T, Doruyter A, Lochner C, Peterburs J, Van Tol M, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Filippi C, Gold A, Harrewijn A, Zugman A, Bülow R, Grabe H, Völzke H, Wittfeld K, Böhnlein J, Dohm K, Kugel H, Schrammen E, Zwanzger P, Leehr E, Sindermann L, Ball T, Fonzo G, Paulus M, Simmons A, Stein M, Klumpp H, Phan K, Furmark T, Månsson K, Manzouri A, Avery S, Blackford J, Clauss J, Feola B, Harper J, Sylvester C, Lueken U, Veltman D, Winkler A, Jahanshad N, Pine D, Thompson P, Stein D, Van der Wee N. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry 2023, 28: 1079-1089. PMID: 36653677, PMCID: PMC10804423, DOI: 10.1038/s41380-022-01933-9.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderSubcortical brain regionsAnxiety disordersSAD patientsBilateral putamen volumesSubcortical regionsBrain regionsLinear mixed effects analysisComorbid anxiety disordersSubcortical volumesFamily-wise errorPutamen volumeSAD onsetVolumetric differencesPallidum volumeMixed effects analysisD effect sizesInconsistent findingsLeft putamenEffect sizeFull samplePrevious findingsInternational sampleSignificant interactionLimited convergence
2020
ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders
Bas‐Hoogendam J, Groenewold N, Aghajani M, Freitag G, Harrewijn A, Hilbert K, Jahanshad N, Thomopoulos S, Thompson P, Veltman D, Winkler A, Lueken U, Pine D, van der Wee N, Stein D, Agosta F, Åhs F, An I, Alberton B, Andreescu C, Asami T, Assaf M, Avery S, Nicholas L, Balderston, Barber J, Battaglia M, Bayram A, Beesdo‐Baum K, Benedetti F, Berta R, Björkstrand J, Blackford J, Blair J, Karina S, Blair, Boehme S, Brambilla P, Burkhouse K, Cano M, Canu E, Cardinale E, Cardoner N, Clauss J, Cividini C, Critchley H, Udo, Dannlowski, Deckert J, Demiralp T, Diefenbach G, Domschke K, Doruyter A, Dresler T, Erhardt A, Fallgatter A, Fañanás L, Brandee, Feola, Filippi C, Filippi M, Fonzo G, Forbes E, Fox N, Fredrikson M, Furmark T, Ge T, Gerber A, Gosnell S, Grabe H, Grotegerd D, Gur R, Gur R, Harmer C, Harper J, Heeren A, Hettema J, Hofmann D, Hofmann S, Jackowski A, Andreas, Jansen, Kaczkurkin A, Kingsley E, Kircher T, c M, Kreifelts B, Krug A, Larsen B, Lee S, Leehr E, Leibenluft E, Lochner C, Maggioni E, Makovac E, Mancini M, Manfro G, Månsson K, Meeten F, Michałowski J, Milrod B, Mühlberger A, Lilianne R, Mujica‐Parodi, Munjiza A, Mwangi B, Myers M, Nenadi C, Neufang S, Nielsen J, Oh H, Ottaviani C, Pan P, Pantazatos S, Martin P, Paulus, Perez‐Edgar K, Peñate W, Perino M, Peterburs J, Pfleiderer B, Phan K, Poletti S, Porta‐Casteràs D, Price R, Pujol J, Andrea, Reinecke, Rivero F, Roelofs K, Rosso I, Saemann P, Salas R, Salum G, Satterthwaite T, Schneier F, Schruers K, Schulz S, Schwarzmeier H, Seeger F, Smoller J, Soares J, Stark R, Stein M, Straube B, Straube T, Strawn J, Suarez‐Jimenez B, Boris, Suchan, Sylvester C, Talati A, Tamburo E, Tükel R, van den Heuvel O, Van der Auwera S, van Nieuwenhuizen H, van Tol M, van Velzen L, Bort C, Vermeiren R, Visser R, Volman I, Wannemüller A, Wendt J, Werwath K, Westenberg P, Wiemer J, Katharina, Wittfeld, Wu M, Yang Y, Zilverstand A, Zugman A, Zwiebel H. ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders. Human Brain Mapping 2020, 43: 83-112. PMID: 32618421, PMCID: PMC8805695, DOI: 10.1002/hbm.25100.Peer-Reviewed Original ResearchConceptsAnxiety disordersSocial anxiety disorderGeneralized anxiety disorderLarge-scale neuroimaging studiesNeuroscience methodologiesNeuroimaging studiesSpecific phobiaGlobal mental healthClinical neuroscienceMental healthPanic disorderENIGMA consortiumUnique sampleDisordersFuture directionsLow statistical powerSmall sample size