2021
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
Harrewijn A, Cardinale E, Groenewold N, Bas-Hoogendam J, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Buckner R, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton B, Benson B, Freitag G, Filippi C, Gold A, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Zugman A, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Grillon C, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball T, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Sylvester C, Yu Q, Lueken U, Veltman D, Thompson P, Stein D, Van der Wee N, Winkler A, Pine D. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry 2021, 11: 502. PMID: 34599145, PMCID: PMC8486763, DOI: 10.1038/s41398-021-01622-1.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderHealthy controlsBrain structuresMain analysisSecondary analysisAnxiety disordersMale healthy controlsVertex-wise cortical thicknessFemale healthy controlsRandom interceptGlobal brain measuresStructural magnetic resonanceCortical surface areaSubcortical brain structuresMedication useYears of educationCortical thicknessSubcortical volumesWorking GroupVentral diencephalonSmall sample sizeBrain measuresInconsistent findingsRight ventral diencephalonMale individuals
2020
ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders
Bas‐Hoogendam J, Groenewold N, Aghajani M, Freitag G, Harrewijn A, Hilbert K, Jahanshad N, Thomopoulos S, Thompson P, Veltman D, Winkler A, Lueken U, Pine D, van der Wee N, Stein D, Agosta F, Åhs F, An I, Alberton B, Andreescu C, Asami T, Assaf M, Avery S, Nicholas L, Balderston, Barber J, Battaglia M, Bayram A, Beesdo‐Baum K, Benedetti F, Berta R, Björkstrand J, Blackford J, Blair J, Karina S, Blair, Boehme S, Brambilla P, Burkhouse K, Cano M, Canu E, Cardinale E, Cardoner N, Clauss J, Cividini C, Critchley H, Udo, Dannlowski, Deckert J, Demiralp T, Diefenbach G, Domschke K, Doruyter A, Dresler T, Erhardt A, Fallgatter A, Fañanás L, Brandee, Feola, Filippi C, Filippi M, Fonzo G, Forbes E, Fox N, Fredrikson M, Furmark T, Ge T, Gerber A, Gosnell S, Grabe H, Grotegerd D, Gur R, Gur R, Harmer C, Harper J, Heeren A, Hettema J, Hofmann D, Hofmann S, Jackowski A, Andreas, Jansen, Kaczkurkin A, Kingsley E, Kircher T, c M, Kreifelts B, Krug A, Larsen B, Lee S, Leehr E, Leibenluft E, Lochner C, Maggioni E, Makovac E, Mancini M, Manfro G, Månsson K, Meeten F, Michałowski J, Milrod B, Mühlberger A, Lilianne R, Mujica‐Parodi, Munjiza A, Mwangi B, Myers M, Nenadi C, Neufang S, Nielsen J, Oh H, Ottaviani C, Pan P, Pantazatos S, Martin P, Paulus, Perez‐Edgar K, Peñate W, Perino M, Peterburs J, Pfleiderer B, Phan K, Poletti S, Porta‐Casteràs D, Price R, Pujol J, Andrea, Reinecke, Rivero F, Roelofs K, Rosso I, Saemann P, Salas R, Salum G, Satterthwaite T, Schneier F, Schruers K, Schulz S, Schwarzmeier H, Seeger F, Smoller J, Soares J, Stark R, Stein M, Straube B, Straube T, Strawn J, Suarez‐Jimenez B, Boris, Suchan, Sylvester C, Talati A, Tamburo E, Tükel R, van den Heuvel O, Van der Auwera S, van Nieuwenhuizen H, van Tol M, van Velzen L, Bort C, Vermeiren R, Visser R, Volman I, Wannemüller A, Wendt J, Werwath K, Westenberg P, Wiemer J, Katharina, Wittfeld, Wu M, Yang Y, Zilverstand A, Zugman A, Zwiebel H. ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders. Human Brain Mapping 2020, 43: 83-112. PMID: 32618421, PMCID: PMC8805695, DOI: 10.1002/hbm.25100.Peer-Reviewed Original ResearchConceptsAnxiety disordersSocial anxiety disorderGeneralized anxiety disorderLarge-scale neuroimaging studiesNeuroscience methodologiesNeuroimaging studiesSpecific phobiaGlobal mental healthClinical neuroscienceMental healthPanic disorderENIGMA consortiumUnique sampleDisordersFuture directionsLow statistical powerSmall sample size