2024
Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders
Roelofs E, Bas-Hoogendam J, Winkler A, van der Wee N, Vermeiren R. Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders. Neuroscience Applied 2024, 3: 104090. DOI: 10.1016/j.nsa.2024.104090.Peer-Reviewed Original ResearchRight laterobasal amygdalaLaterobasal amygdalaWhole-brain networksAmygdala subregionsFunctional connectivityCentromedial amygdalaSymptom changeFrontal poleInternalizing disordersPostcentral gyrusResting-state functional magnetic resonance imagingResting-state functional connectivityFunctional magnetic resonance imagingICA-derived networksClinically representative sampleFC developmentNonspecific treatment effectsRs-fMRI scansIndependent component analysisResting-state networksLongitudinal developmentCare-as-usualComorbid anxietyNeuroimaging researchBilateral seeds
2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspects
2020
Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months
Filippi C, Ravi S, Bracy M, Winkler A, Sylvester C, Pine D, Fox N. Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1137-1146. PMID: 33385507, PMCID: PMC8239057, DOI: 10.1016/j.jaac.2020.11.021.Peer-Reviewed Original ResearchConceptsAmygdala connectivityPositive affectNegative affectParent reportChild-reported anxiety symptomsCognitive control mechanismsFunctional magnetic resonance imagingWhole-brain voxelwise approachLow positive affectAmygdala functional connectivityResting-state functional magnetic resonance imagingIndependent longitudinal samplesReactivity assessmentTemperamental riskReactive temperamentInfant temperamentAnxiety symptomsConnectivity correlatesLongitudinal sampleFunctional connectivityMaternal reportsNegative reactivityAffectTemperamentDistress