2021
Patients with chronic pain exhibit individually unique cortical signatures of pain encoding
Mayr A, Jahn P, Stankewitz A, Deak B, Winkler A, Witkovsky V, Eren O, Straube A, Schulz E. Patients with chronic pain exhibit individually unique cortical signatures of pain encoding. Human Brain Mapping 2021, 43: 1676-1693. PMID: 34921467, PMCID: PMC8886665, DOI: 10.1002/hbm.25750.Peer-Reviewed Original ResearchConceptsChronic back painEndogenous painAnterior insular cortexBack painChronic painInsular cortexCortical signaturesChronic pain exhibitChronic migraine patientsChange of painIntensity of painFunctional MRI sessionsUnique cortical signaturesChronic migrainePain intensityMigraine patientsPainMultifaceted diseaseClinical observationsPatientsLinear mixed effects modelsFrontal operculumMRI sessionsMixed effects modelsCortical processes
2020
Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain
Schulz E, Stankewitz A, Winkler A, Irving S, Witkovský V, Tracey I. Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain. ELife 2020, 9: e55028. PMID: 32876049, PMCID: PMC7498261, DOI: 10.7554/elife.55028.Peer-Reviewed Original ResearchConceptsPain attenuationBrain connectivityAttenuation of painCognitive strategiesHigher functional connectivityWhole-brain connectivityTonic cold painWhite matter integrityPain processingLower painFunctional imaging dataCold painPainCingulate cortexBrain regionsFunctional connectivityHealthy participantsTrialsCognitive interventionsDiffusion tensorTrial variabilityBrain dataImaging dataParticipants