2024
Topological cluster statistic (TCS): Toward structural connectivity–guided fMRI cluster enhancement
L. S, Seguin C, Winkler A, Noble S, Zalesky A. Topological cluster statistic (TCS): Toward structural connectivity–guided fMRI cluster enhancement. Network Neuroscience 2024, 8: 902-925. PMID: 39355436, PMCID: PMC11424043, DOI: 10.1162/netn_a_00375.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAbstract Functional magnetic resonance imagingBrain activityAnatomical connectivity informationMedium-sized effectsCluster-based inferenceMultimodal informationConnectivity informationAnatomical underpinningsActive inferenceNeuroimaging analysisAnatomical networksDiffusion tractographyOptimal inferenceInsufficient statistical powerWidespread activationMagnetic resonance imagingFunctional imagingConventional approachesDetect local changesInferenceBrainResonance imagingStatistical powerUsability
2023
Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy
Casella C, Vecchiato K, Cromb D, Guo Y, Winkler A, Hughes E, Dillon L, Green E, Colford K, Egloff A, Siddiqui A, Price A, Grande L, Wood T, Malik S, Teixeira R, Carmichael D, O'Muircheartaigh J. Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy. Epilepsia 2023, 65: 739-752. PMID: 38088235, PMCID: PMC7616339, DOI: 10.1111/epi.17861.Peer-Reviewed Original ResearchDrug-resistant focal epilepsyFocal epilepsyMagnetic resonance imagingTreatment-related side effectsMRI-positive patientsMRI-negative patientsDisease severity measuresWidespread cortical areasPediatric focal epilepsyQuantitative magnetic resonance imagingPeriod of onsetTissue microstructural changesRadiological abnormalitiesUnderlying pathophysiologyHealthy controlsIndividual patientsCortical areasDisease processSide effectsPatientsFocal pathologyEpilepsyNeurobiological alterationsDisease severityResonance imaging
2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspectsSARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson J, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler A, Collins R, Matthews P, Allen N, Miller K, Nichols T, Smith S. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022, 604: 697-707. PMID: 35255491, PMCID: PMC9046077, DOI: 10.1038/s41586-022-04569-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pre-existing risk factorsSARS-CoV-2 infectionSARS-CoV-2 casesPrimary olfactory cortexGreater reductionUK BiobankGreater cognitive declineMagnetic resonance imagingGray matter thicknessLongitudinal effectsNeuroinflammatory eventsRisk factorsOlfactory cortexMild casesBrain changesBrain pathologyCOVID-191Parahippocampal gyrusBrain imaging resultsCognitive declineTissue damageResonance imagingOlfactory pathwayOrbitofrontal cortex
2021
The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping
Thompson P, Jahanshad N, Schmaal L, Turner J, Winkler A, Thomopoulos S, Egan G, Kochunov P. The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping. Human Brain Mapping 2021, 43: 15-22. PMID: 34612558, PMCID: PMC8675422, DOI: 10.1002/hbm.25672.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMeta-Analysis (ENIGMA) consortiumEnhancing Neuroimaging GeneticsBrain developmentBrain mappingHuman brain mappingBrain mapping analysisTask-based functional magnetic resonance imagingSubstance use disordersFunctional magnetic resonance imagingPosttraumatic stress disorderHuman brain disordersHuman brain developmentObsessive-compulsive disorderDiffusion magnetic resonance imagingMajor depressionUse disordersBipolar disorderBrain disordersBrain scansResonance imagingMagnetic resonance spectroscopyHuman cortexStress disorderLarge-scale studiesAllocentric representation in the human amygdala and ventral visual stream
Evensmoen H, Rimol L, Winkler A, Betzel R, Hansen T, Nili H, Håberg A. Allocentric representation in the human amygdala and ventral visual stream. Cell Reports 2021, 34: 108658. PMID: 33472067, DOI: 10.1016/j.celrep.2020.108658.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMedial temporal lobeVentral visual streamHigh-resolution functional magnetic resonance imagingMagnetic resonance imagingBrain activation patternsDistinct neural populationsVisual streamMain brain structuresEntorhinal cortexTemporal lobePerirhinal cortexResonance imagingParahippocampal cortexBrain structuresCortexHippocampusAmygdalaFusiform cortexActivation patternsHuman amygdalaYoung menNeural populationsAllocentric representationsConnector hubs
2017
The heritability of multi-modal connectivity in human brain activity
Colclough G, Smith S, Nichols T, Winkler A, Sotiropoulos S, Glasser M, Van Essen D, Woolrich M. The heritability of multi-modal connectivity in human brain activity. ELife 2017, 6: e20178. PMID: 28745584, PMCID: PMC5621837, DOI: 10.7554/elife.20178.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingFunctional connectivity profilesNeuronal activityResonance imagingCortical regionsFunctional connectivityFMRI connectivityGenetic factorsConnectivity profilesMagnetoencephalographic recordingsBrain activityCognitive performanceHuman brain activityHuman Connectome ProjectMulti-modal connectivityConnectome ProjectDisease
2016
Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation
Klaassens B, Rombouts S, Winkler A, van Gorsel H, van der Grond J, van Gerven J. Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation. Human Brain Mapping 2016, 38: 308-325. PMID: 27622387, PMCID: PMC5215384, DOI: 10.1002/hbm.23362.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingCholinergic AgentsCholinesterase InhibitorsCitalopramCross-Over StudiesDouble-Blind MethodFemaleGalantamineHumansHydrocortisoneImage Processing, Computer-AssistedMaleModels, NeurologicalOxygenProlactinSelective Serotonin Reuptake InhibitorsSerotoninYoung AdultConceptsFunctional magnetic resonance imagingState functional magnetic resonance imagingSelf-referential mechanismCognitive performanceNeurotransmitter systemsVisual perceptionAcetylcholinesterase inhibitor galantamineSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramFunctional connectivityRs-fMRI scansSensorimotor networkReuptake inhibitor citalopramBrain neurotransmitter systemsFunctional networksPsychopharmacological researchHealthy young volunteersTime-specific effectsMagnetic resonance imagingGroup comparisonsState networksCrossover studySerotonergic stimulationAcute influenceHeart rateIpsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Allman C, Amadi U, Winkler A, Wilkins L, Filippini N, Kischka U, Stagg C, Johansen-Berg H. Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke. Science Translational Medicine 2016, 8: 330re1. PMID: 27089207, PMCID: PMC5388180, DOI: 10.1126/scitranslmed.aad5651.Peer-Reviewed Original ResearchConceptsAnodal transcranial direct current stimulationTranscranial direct current stimulationAction Research Arm TestWolf Motor Function TestMagnetic resonance imagingMotor trainingPremotor cortexIpsilesional motorSham treatmentFunctional magnetic resonance imagingUpper extremity Fugl-Meyer scoreDaily motor trainingLong-term clinical outcomesAnodal tDCS groupFirst unilateral strokeDirect current stimulationIntervention-related increasesFugl-Meyer scoreSham treatment groupMotor Function TestMotor training programPrimary motor cortexStructural magnetic resonance imagingGray matter volumeMotor learning
2014
Interaction of brain areas of visual and vestibular simultaneous activity with fMRI
Della-Justina H, Gamba H, Lukasova K, Nucci-da-Silva M, Winkler A, Amaro E. Interaction of brain areas of visual and vestibular simultaneous activity with fMRI. Experimental Brain Research 2014, 233: 237-252. PMID: 25300959, DOI: 10.1007/s00221-014-4107-6.Peer-Reviewed Original ResearchConceptsNegative BOLD responseSimultaneous stimulationPrecentral gyrusBrain areasVestibular systemParieto-insular vestibular cortexVisual stimulationVisual-vestibular stimuliNon-symptomatic subjectsFunctional magnetic resonance imagingMagnetic resonance imagingAssociative visual cortexLevel-dependent responsesSuperior temporal gyrusInferior parietal lobeVestibular cortexCalcarine gyrusInferior frontal gyrusVestibular inputCerebellar hemisphereVestibular stimulationTemporal lobeLingual gyrusParietal lobeAssociation areasGalvanic vestibular stimulator for fMRI studies
Della-Justina H, Manczak T, Winkler A, de Araújo D, de Souza M, Amaro E, Gamba H. Galvanic vestibular stimulator for fMRI studies. Research On Biomedical Engineering 2014, 30: 70-82. DOI: 10.4322/rbeb.2013.046.Peer-Reviewed Original ResearchGalvanic vestibular stimulationFunctional magnetic resonance imagingVestibular stimulationPain sensationVestibular systemLess pain sensationSupplementary motor areaMiddle cingulate cortexMagnetic resonance imagingInferior parietal lobuleSuperior temporal gyrusGalvanic stimulationInferior frontal gyrusPostcentral gyrusMotor areaMRI scanner roomCentral sulcusCingulate cortexResonance imagingHuman volunteersParietal lobuleTemporal gyrusFrontal gyrusGyrusMRI room
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions