2021
Patients with chronic pain exhibit individually unique cortical signatures of pain encoding
Mayr A, Jahn P, Stankewitz A, Deak B, Winkler A, Witkovsky V, Eren O, Straube A, Schulz E. Patients with chronic pain exhibit individually unique cortical signatures of pain encoding. Human Brain Mapping 2021, 43: 1676-1693. PMID: 34921467, PMCID: PMC8886665, DOI: 10.1002/hbm.25750.Peer-Reviewed Original ResearchConceptsChronic back painEndogenous painAnterior insular cortexBack painChronic painInsular cortexCortical signaturesChronic pain exhibitChronic migraine patientsChange of painIntensity of painFunctional MRI sessionsUnique cortical signaturesChronic migrainePain intensityMigraine patientsPainMultifaceted diseaseClinical observationsPatientsLinear mixed effects modelsFrontal operculumMRI sessionsMixed effects modelsCortical processes
2019
Strategy-dependent modulation of cortical pain circuits for the attenuation of pain
Schulz E, Stankewitz A, Witkovský V, Winkler A, Tracey I. Strategy-dependent modulation of cortical pain circuits for the attenuation of pain. Cortex 2019, 113: 255-266. PMID: 30711854, DOI: 10.1016/j.cortex.2018.12.014.Peer-Reviewed Original ResearchConceptsCognitive strategiesBrain activityDifferent cognitive strategiesPain attenuationUnderlying neuronal mechanismsPain-related brain activityVariability of performanceNeuroscientific techniquesNeurofeedback techniquesT fMRIPerception of painBehavioral dataBehavioral studiesTrial levelBrain regionsCortical regionsNeuronal mechanismsCortical feedbackInsular cortexDistractionTaskPain perceptionPotential predispositionAttenuation of painPerception