Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation