2023
Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy
Casella C, Vecchiato K, Cromb D, Guo Y, Winkler A, Hughes E, Dillon L, Green E, Colford K, Egloff A, Siddiqui A, Price A, Grande L, Wood T, Malik S, Teixeira R, Carmichael D, O'Muircheartaigh J. Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy. Epilepsia 2023, 65: 739-752. PMID: 38088235, PMCID: PMC7616339, DOI: 10.1111/epi.17861.Peer-Reviewed Original ResearchDrug-resistant focal epilepsyFocal epilepsyMagnetic resonance imagingTreatment-related side effectsMRI-positive patientsMRI-negative patientsDisease severity measuresWidespread cortical areasPediatric focal epilepsyQuantitative magnetic resonance imagingPeriod of onsetTissue microstructural changesRadiological abnormalitiesUnderlying pathophysiologyHealthy controlsIndividual patientsCortical areasDisease processSide effectsPatientsFocal pathologyEpilepsyNeurobiological alterationsDisease severityResonance imaging
2021
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
Harrewijn A, Cardinale E, Groenewold N, Bas-Hoogendam J, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Buckner R, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton B, Benson B, Freitag G, Filippi C, Gold A, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Zugman A, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Grillon C, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball T, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Sylvester C, Yu Q, Lueken U, Veltman D, Thompson P, Stein D, Van der Wee N, Winkler A, Pine D. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry 2021, 11: 502. PMID: 34599145, PMCID: PMC8486763, DOI: 10.1038/s41398-021-01622-1.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderHealthy controlsBrain structuresMain analysisSecondary analysisAnxiety disordersMale healthy controlsVertex-wise cortical thicknessFemale healthy controlsRandom interceptGlobal brain measuresStructural magnetic resonanceCortical surface areaSubcortical brain structuresMedication useYears of educationCortical thicknessSubcortical volumesWorking GroupVentral diencephalonSmall sample sizeBrain measuresInconsistent findingsRight ventral diencephalonMale individuals
2019
One-year changes in brain microstructure differentiate preclinical Huntington's disease stages
Pflanz C, Charquero-Ballester M, Majid D, Winkler A, Vallée E, Aron A, Jenkinson M, Douaud G. One-year changes in brain microstructure differentiate preclinical Huntington's disease stages. NeuroImage Clinical 2019, 25: 102099. PMID: 31865023, PMCID: PMC6931230, DOI: 10.1016/j.nicl.2019.102099.Peer-Reviewed Original ResearchConceptsOnset of symptomsPreclinical stageDisease stageMean diffusivityHuntington's diseaseGender-matched healthy controlsOnly clinical measurePosterior basal gangliaDistinct pathophysiological mechanismsOptimal therapeutic windowOne-year changeSignificant differencesPreclinical Huntington's diseasePresymptomatic Huntington's diseaseNeurodegenerative phaseNeuroinflammatory processesMotor scoresPathophysiological mechanismsBasal gangliaDisease progressionHealthy controlsHuntington's disease stagesCorpus callosumTreatment responseClinical measures