2022
tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel
Nandi T, Puonti O, Clarke W, Nettekoven C, Barron H, Kolasinski J, Hanayik T, Hinson E, Berrington A, Bachtiar V, Johnstone A, Winkler A, Thielscher A, Johansen-Berg H, Stagg C. tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel. Brain Stimulation 2022, 15: 1153-1162. PMID: 35988862, PMCID: PMC7613675, DOI: 10.1016/j.brs.2022.07.049.Peer-Reviewed Original ResearchComputational modeling of threat learning reveals links with anxiety and neuroanatomy in humans
Abend R, Burk D, Ruiz S, Gold A, Napoli J, Britton J, Michalska K, Shechner T, Winkler A, Leibenluft E, Pine D, Averbeck B. Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans. ELife 2022, 11: e66169. PMID: 35473766, PMCID: PMC9197395, DOI: 10.7554/elife.66169.Peer-Reviewed Original ResearchConceptsThreat learningAnxiety severitySafety learningNeuroanatomical substratesGreater anxiety severitySkin conductance dataThreat conditioningThreat extinctionThreat generalizationGray matter volumeSafe stimuliAssociative learningComputational mechanismsAnxiety symptomsAnxiety disordersInfluential theoriesSlower extinctionComputational modelLearningWhole brain anatomyAnxietyComputational modelingStructural imagingStimuliTask
2020
The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure
Sexton C, Betts J, Dennis A, Doherty A, Leeson P, Holloway C, Dall'Armellina E, Winkler A, Demnitz N, Wassenaar T, Dawes H, Johansen-Berg H. The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure. Physiology & Behavior 2020, 223: 112923. PMID: 32474233, PMCID: PMC7378567, DOI: 10.1016/j.physbeh.2020.112923.Peer-Reviewed Original ResearchConceptsAerobic training programGray matter volumeCardiorespiratory fitnessMatter volumeMagnetic resonance imaging outcomesSpecific high-risk populationsBrain structuresOlder adultsAerobic training interventionHigh-risk populationStructural MRI analysisTract-based spatial statisticsVoxel-based morphometryVoxel-wise assessmentWaitlist control conditionHealthy older adultsWhite matter microstructureImaging outcomesHippocampal volumeObservational studyPhysical activityReduced riskCognitive declineMax testingMore encouraging results
2017
Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia
Rowland M, Ezra M, Winkler A, Garry P, Lamb C, Kelly M, Okell T, Westbrook J, Wise R, Douaud G, Pattinson K. Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia. Cerebrovascular And Brain Metabolism Reviews 2017, 39: 285-301. PMID: 28857714, PMCID: PMC6360646, DOI: 10.1177/0271678x17726624.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientAcute hypoxiaAcute cerebral hypoxiaCalcium channel blockadeCalcium channel antagonismSignificant decreaseCalcium channel antagonistsState functional MRIIntracellular calcium fluxBrain responsesGray matter volumeSame brain regionsEffects of hypoxiaCerebral edemaCerebral hypoxiaNeuronal damageMRI evidenceChannel antagonismCytotoxic edemaChannel antagonistsChannel blockadeClinical conditionsMultiparametric MRIMatter volumeWhole brain
2016
Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Allman C, Amadi U, Winkler A, Wilkins L, Filippini N, Kischka U, Stagg C, Johansen-Berg H. Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke. Science Translational Medicine 2016, 8: 330re1. PMID: 27089207, PMCID: PMC5388180, DOI: 10.1126/scitranslmed.aad5651.Peer-Reviewed Original ResearchConceptsAnodal transcranial direct current stimulationTranscranial direct current stimulationAction Research Arm TestWolf Motor Function TestMagnetic resonance imagingMotor trainingPremotor cortexIpsilesional motorSham treatmentFunctional magnetic resonance imagingUpper extremity Fugl-Meyer scoreDaily motor trainingLong-term clinical outcomesAnodal tDCS groupFirst unilateral strokeDirect current stimulationIntervention-related increasesFugl-Meyer scoreSham treatment groupMotor Function TestMotor training programPrimary motor cortexStructural magnetic resonance imagingGray matter volumeMotor learning