2022
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson J, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler A, Collins R, Matthews P, Allen N, Miller K, Nichols T, Smith S. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022, 604: 697-707. PMID: 35255491, PMCID: PMC9046077, DOI: 10.1038/s41586-022-04569-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pre-existing risk factorsSARS-CoV-2 infectionSARS-CoV-2 casesPrimary olfactory cortexGreater reductionUK BiobankGreater cognitive declineMagnetic resonance imagingGray matter thicknessLongitudinal effectsNeuroinflammatory eventsRisk factorsOlfactory cortexMild casesBrain changesBrain pathologyCOVID-191Parahippocampal gyrusBrain imaging resultsCognitive declineTissue damageResonance imagingOlfactory pathwayOrbitofrontal cortex
2019
Short-interval intracortical inhibition is decreased in restless legs syndrome across a range of severity
Magalhães S, Queiroz de Paiva J, Kaelin-Lang A, Sterr A, Eckeli A, Winkler A, Fernandes do Prado G, Amaro E, Conforto A. Short-interval intracortical inhibition is decreased in restless legs syndrome across a range of severity. Sleep Medicine 2019, 62: 34-42. PMID: 31539846, DOI: 10.1016/j.sleep.2019.03.021.Peer-Reviewed Original ResearchConceptsShort-interval intracortical inhibitionRLS/WEDCortical thicknessIntracortical inhibitionRestless legs syndrome/Willis-Ekbom diseaseRestless legs syndromePrimary motor cortexWillis-Ekbom diseaseCharacteristic curve analysisGray matter thicknessDiscrimination of participantsIdiopathic mildRange of severityLegs syndromeMotor cortexMagnetic resonance imaging dataMild symptomsSurface-based analysisSeverity ScaleCortical areasMagnetic stimulationWhole brainCurve analysisCharacteristic curveSeverity