2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions
2010
Genetic control over the resting brain
Glahn DC, Winkler AM, Kochunov P, Almasy L, Duggirala R, Carless MA, Curran JC, Olvera RL, Laird AR, Smith SM, Beckmann CF, Fox PT, Blangero J. Genetic control over the resting brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 1223-1228. PMID: 20133824, PMCID: PMC2824276, DOI: 10.1073/pnas.0909969107.Peer-Reviewed Original ResearchConceptsDefault-mode functional connectivityDefault mode connectivityFunctional connectivityDefault mode networkGenetic factorsPosterior cingulate/precuneus regionBasal neural activityResting-state brain networksGray matter densityMedial prefrontal cortexLeft parahippocampal regionIntrinsic brain functionPsychiatric illnessNeurological illnessNeurophysiologic mechanismsAnatomic variationsRight cerebellumSuch illnessesParahippocampal regionBrain functionPrecuneus regionsPrefrontal cortexIllnessGenetic riskNeural activity