2024
The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease
Manuello J, Min J, McCarthy P, Alfaro-Almagro F, Lee S, Smith S, Elliott L, Winkler A, Douaud G. The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease. Nature Communications 2024, 15: 2576. PMID: 38538590, PMCID: PMC10973379, DOI: 10.1038/s41467-024-46344-2.Peer-Reviewed Original ResearchConceptsModifiable risk factorsRisk factorsBrain networksUK Biobank participantsTraffic-related air pollutionAlcohol intake frequencyBrain regionsGenome-wide associationBiobank participantsHigher-order brain regionsIntake frequencyXg blood groupEffects of ageCardiovascular deathGenetic influencesUnique contributionsNitrogen dioxideSchizophreniaBrainAgeAir pollutionAlzheimer's diseaseParkinson's diseaseSexAssociation
2015
Genetic Influence on the Human Brain
McKay D, Winkler A, Kochunov P, Knowles E, Sprooten E, Fox P, Blangero J, Glahn D. Genetic Influence on the Human Brain. Genome Mapping And Genomics In Animals 2015, 247-258. DOI: 10.1007/978-3-662-46306-2_13.Peer-Reviewed Original ResearchProgram of discoveryGenetic elementsGenetic underpinningsBasic neuroscienceBrain functionBrain structuresHuman brainGenetic influencesNeuroscienceNeuroscience componentFundamental neuroscienceGenetic search spacePrevalent disorderOverarching goalDiscoveryGenesSystematic programGeneticsImage-based featuresPhenotypeUnderpinningsMaturationLongevityDisordersImplications