2015
Genetic Influence on the Human Brain
McKay D, Winkler A, Kochunov P, Knowles E, Sprooten E, Fox P, Blangero J, Glahn D. Genetic Influence on the Human Brain. Genome Mapping And Genomics In Animals 2015, 247-258. DOI: 10.1007/978-3-662-46306-2_13.Peer-Reviewed Original ResearchProgram of discoveryGenetic elementsGenetic underpinningsBasic neuroscienceBrain functionBrain structuresHuman brainGenetic influencesNeuroscienceNeuroscience componentFundamental neuroscienceGenetic search spacePrevalent disorderOverarching goalDiscoveryGenesSystematic programGeneticsImage-based featuresPhenotypeUnderpinningsMaturationLongevityDisordersImplications
2013
Transcriptomics of cortical gray matter thickness decline during normal aging
Kochunov P, Charlesworth J, Winkler A, Hong LE, Nichols TE, Curran JE, Sprooten E, Jahanshad N, Thompson PM, Johnson MP, Kent JW, Landman BA, Mitchell B, Cole SA, Dyer TD, Moses EK, Goring HH, Almasy L, Duggirala R, Olvera RL, Glahn DC, Blangero J. Transcriptomics of cortical gray matter thickness decline during normal aging. NeuroImage 2013, 82: 273-283. PMID: 23707588, PMCID: PMC3759649, DOI: 10.1016/j.neuroimage.2013.05.066.Peer-Reviewed Original ResearchConceptsPathway enrichment analysisTranscriptome dataInnate immune pathwaysEnrichment analysisCellular proliferationInnate immune response pathwaysImmune pathwaysImmune response pathwaysResponse pathwaysFunctional categoriesPathway enrichmentTranscriptional activityGenesExpression activityTranscriptsHigh-resolution T1-weighted MRINormal cerebral agingCommunity-dwelling membersPathwaySignificance thresholdRegenerative capacityT1-weighted MRIDifferentiationCerebral agingViral infection
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insightsGenetic Architecture of Declarative Memory
Bearden CE, Karlsgodt KH, Bachman P, van Erp TG, Winkler AM, Glahn DC. Genetic Architecture of Declarative Memory. The Neuroscientist 2011, 18: 516-532. PMID: 21832260, PMCID: PMC3545476, DOI: 10.1177/1073858411415113.Peer-Reviewed Original ResearchConceptsGenetic architectureIndependent inheritanceGenetic basisMolecular basisSingle gene disordersMolecular mechanismsGeneralist genesMemory functionHuman memory functionLong-term memoryDistinct aspectsGenesDeclarative memoryCognitive domainsMemory abilityDistinct subcomponentsInheritanceMemoryFunctionIndividual variabilityDomainImportant informationEvidence