2024
Topological cluster statistic (TCS): Toward structural connectivity–guided fMRI cluster enhancement
L. S, Seguin C, Winkler A, Noble S, Zalesky A. Topological cluster statistic (TCS): Toward structural connectivity–guided fMRI cluster enhancement. Network Neuroscience 2024, 8: 902-925. PMID: 39355436, PMCID: PMC11424043, DOI: 10.1162/netn_a_00375.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAbstract Functional magnetic resonance imagingBrain activityAnatomical connectivity informationMedium-sized effectsCluster-based inferenceMultimodal informationConnectivity informationAnatomical underpinningsActive inferenceNeuroimaging analysisAnatomical networksDiffusion tractographyOptimal inferenceInsufficient statistical powerWidespread activationMagnetic resonance imagingFunctional imagingConventional approachesDetect local changesInferenceBrainResonance imagingStatistical powerUsabilityLongitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders
Roelofs E, Bas-Hoogendam J, Winkler A, van der Wee N, Vermeiren R. Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders. Neuroscience Applied 2024, 3: 104090. DOI: 10.1016/j.nsa.2024.104090.Peer-Reviewed Original ResearchRight laterobasal amygdalaLaterobasal amygdalaWhole-brain networksAmygdala subregionsFunctional connectivityCentromedial amygdalaSymptom changeFrontal poleInternalizing disordersPostcentral gyrusResting-state functional magnetic resonance imagingResting-state functional connectivityFunctional magnetic resonance imagingICA-derived networksClinically representative sampleFC developmentNonspecific treatment effectsRs-fMRI scansIndependent component analysisResting-state networksLongitudinal developmentCare-as-usualComorbid anxietyNeuroimaging researchBilateral seeds
2023
Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses
Leerssen J, Aghajani M, Bresser T, Rösler L, Winkler A, Foster-Dingley J, Van Someren E. Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 60-69. PMID: 36958474, DOI: 10.1016/j.bpsc.2023.03.007.Peer-Reviewed Original ResearchConceptsAmygdala responseSleep interventionsEmotion-related brain activityFunctional magnetic resonance imaging studyEmotional brain responsesInsomnia treatmentFunctional magnetic resonance imagingCognitive behavioral therapyMagnetic resonance imaging studyEmotional stimuliResonance imaging studyBrain mechanismsIndividual differencesPrevention of depressionCircadian interventionsBrain responsesEmotional stabilityBehavioral therapyAnxiety severityBrain activityBrain responsivenessLeft insulaInsomnia disorderHigh riskInsomnia symptoms
2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspects
2021
The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping
Thompson P, Jahanshad N, Schmaal L, Turner J, Winkler A, Thomopoulos S, Egan G, Kochunov P. The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping. Human Brain Mapping 2021, 43: 15-22. PMID: 34612558, PMCID: PMC8675422, DOI: 10.1002/hbm.25672.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMeta-Analysis (ENIGMA) consortiumEnhancing Neuroimaging GeneticsBrain developmentBrain mappingHuman brain mappingBrain mapping analysisTask-based functional magnetic resonance imagingSubstance use disordersFunctional magnetic resonance imagingPosttraumatic stress disorderHuman brain disordersHuman brain developmentObsessive-compulsive disorderDiffusion magnetic resonance imagingMajor depressionUse disordersBipolar disorderBrain disordersBrain scansResonance imagingMagnetic resonance spectroscopyHuman cortexStress disorderLarge-scale studiesAllocentric representation in the human amygdala and ventral visual stream
Evensmoen H, Rimol L, Winkler A, Betzel R, Hansen T, Nili H, Håberg A. Allocentric representation in the human amygdala and ventral visual stream. Cell Reports 2021, 34: 108658. PMID: 33472067, DOI: 10.1016/j.celrep.2020.108658.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMedial temporal lobeVentral visual streamHigh-resolution functional magnetic resonance imagingMagnetic resonance imagingBrain activation patternsDistinct neural populationsVisual streamMain brain structuresEntorhinal cortexTemporal lobePerirhinal cortexResonance imagingParahippocampal cortexBrain structuresCortexHippocampusAmygdalaFusiform cortexActivation patternsHuman amygdalaYoung menNeural populationsAllocentric representationsConnector hubs
2020
Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months
Filippi C, Ravi S, Bracy M, Winkler A, Sylvester C, Pine D, Fox N. Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1137-1146. PMID: 33385507, PMCID: PMC8239057, DOI: 10.1016/j.jaac.2020.11.021.Peer-Reviewed Original ResearchConceptsAmygdala connectivityPositive affectNegative affectParent reportChild-reported anxiety symptomsCognitive control mechanismsFunctional magnetic resonance imagingWhole-brain voxelwise approachLow positive affectAmygdala functional connectivityResting-state functional magnetic resonance imagingIndependent longitudinal samplesReactivity assessmentTemperamental riskReactive temperamentInfant temperamentAnxiety symptomsConnectivity correlatesLongitudinal sampleFunctional connectivityMaternal reportsNegative reactivityAffectTemperamentDistress
2017
The heritability of multi-modal connectivity in human brain activity
Colclough G, Smith S, Nichols T, Winkler A, Sotiropoulos S, Glasser M, Van Essen D, Woolrich M. The heritability of multi-modal connectivity in human brain activity. ELife 2017, 6: e20178. PMID: 28745584, PMCID: PMC5621837, DOI: 10.7554/elife.20178.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingFunctional connectivity profilesNeuronal activityResonance imagingCortical regionsFunctional connectivityFMRI connectivityGenetic factorsConnectivity profilesMagnetoencephalographic recordingsBrain activityCognitive performanceHuman brain activityHuman Connectome ProjectMulti-modal connectivityConnectome ProjectDisease
2016
Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation
Klaassens B, Rombouts S, Winkler A, van Gorsel H, van der Grond J, van Gerven J. Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation. Human Brain Mapping 2016, 38: 308-325. PMID: 27622387, PMCID: PMC5215384, DOI: 10.1002/hbm.23362.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingCholinergic AgentsCholinesterase InhibitorsCitalopramCross-Over StudiesDouble-Blind MethodFemaleGalantamineHumansHydrocortisoneImage Processing, Computer-AssistedMaleModels, NeurologicalOxygenProlactinSelective Serotonin Reuptake InhibitorsSerotoninYoung AdultConceptsFunctional magnetic resonance imagingState functional magnetic resonance imagingSelf-referential mechanismCognitive performanceNeurotransmitter systemsVisual perceptionAcetylcholinesterase inhibitor galantamineSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramFunctional connectivityRs-fMRI scansSensorimotor networkReuptake inhibitor citalopramBrain neurotransmitter systemsFunctional networksPsychopharmacological researchHealthy young volunteersTime-specific effectsMagnetic resonance imagingGroup comparisonsState networksCrossover studySerotonergic stimulationAcute influenceHeart rateIpsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Allman C, Amadi U, Winkler A, Wilkins L, Filippini N, Kischka U, Stagg C, Johansen-Berg H. Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke. Science Translational Medicine 2016, 8: 330re1. PMID: 27089207, PMCID: PMC5388180, DOI: 10.1126/scitranslmed.aad5651.Peer-Reviewed Original ResearchConceptsAnodal transcranial direct current stimulationTranscranial direct current stimulationAction Research Arm TestWolf Motor Function TestMagnetic resonance imagingMotor trainingPremotor cortexIpsilesional motorSham treatmentFunctional magnetic resonance imagingUpper extremity Fugl-Meyer scoreDaily motor trainingLong-term clinical outcomesAnodal tDCS groupFirst unilateral strokeDirect current stimulationIntervention-related increasesFugl-Meyer scoreSham treatment groupMotor Function TestMotor training programPrimary motor cortexStructural magnetic resonance imagingGray matter volumeMotor learning
2014
Interaction of brain areas of visual and vestibular simultaneous activity with fMRI
Della-Justina H, Gamba H, Lukasova K, Nucci-da-Silva M, Winkler A, Amaro E. Interaction of brain areas of visual and vestibular simultaneous activity with fMRI. Experimental Brain Research 2014, 233: 237-252. PMID: 25300959, DOI: 10.1007/s00221-014-4107-6.Peer-Reviewed Original ResearchConceptsNegative BOLD responseSimultaneous stimulationPrecentral gyrusBrain areasVestibular systemParieto-insular vestibular cortexVisual stimulationVisual-vestibular stimuliNon-symptomatic subjectsFunctional magnetic resonance imagingMagnetic resonance imagingAssociative visual cortexLevel-dependent responsesSuperior temporal gyrusInferior parietal lobeVestibular cortexCalcarine gyrusInferior frontal gyrusVestibular inputCerebellar hemisphereVestibular stimulationTemporal lobeLingual gyrusParietal lobeAssociation areasGalvanic vestibular stimulator for fMRI studies
Della-Justina H, Manczak T, Winkler A, de Araújo D, de Souza M, Amaro E, Gamba H. Galvanic vestibular stimulator for fMRI studies. Research On Biomedical Engineering 2014, 30: 70-82. DOI: 10.4322/rbeb.2013.046.Peer-Reviewed Original ResearchGalvanic vestibular stimulationFunctional magnetic resonance imagingVestibular stimulationPain sensationVestibular systemLess pain sensationSupplementary motor areaMiddle cingulate cortexMagnetic resonance imagingInferior parietal lobuleSuperior temporal gyrusGalvanic stimulationInferior frontal gyrusPostcentral gyrusMotor areaMRI scanner roomCentral sulcusCingulate cortexResonance imagingHuman volunteersParietal lobuleTemporal gyrusFrontal gyrusGyrusMRI room