2024
Current and Future Approaches to Pediatric Anxiety Disorder Treatment
Zugman A, Winkler A, Qamar P, Pine D. Current and Future Approaches to Pediatric Anxiety Disorder Treatment. American Journal Of Psychiatry 2024, 181: 189-200. PMID: 38425255, PMCID: PMC11256210, DOI: 10.1176/appi.ajp.20231037.Peer-Reviewed Original Research
2023
A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward
Zugman A, Jett L, Antonacci C, Winkler A, Pine D. A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward. Journal Of Anxiety Disorders 2023, 99: 102773. PMID: 37741177, PMCID: PMC10753861, DOI: 10.1016/j.janxdis.2023.102773.Peer-Reviewed Original ResearchConceptsAnxiety disordersSystematic reviewPrevalent psychiatric disordersStrict inclusion criteriaAnterior cingulate cortexMedial frontal gyrusActivation likelihood estimation (ALE) analysisResting-state fMRITime of scanningFunctional imaging modalitiesPatient groupHealthy groupInclusion criteriaHealthy volunteersPsychiatric disordersCingulate cortexStudy numbersRs-fMRIFrontal gyrusDisordersImaging modalitiesPatientsBrain activityFamily-wise errorGyrus
2022
Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration
Khosravi P, Zugman A, Amelio P, Winkler A, Pine D. Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration. Current Psychiatry Reports 2022, 24: 841-851. PMID: 36469202, PMCID: PMC9931491, DOI: 10.1007/s11920-022-01385-6.Peer-Reviewed Original ResearchConceptsAnxiety disordersError Related NegativityPediatric anxiety disordersMost anxiety disordersDisorder treatment outcomesAnxious individualsNeural correlatesMultimodal integrationNeural markersGroup differencesResponse/outcomesAnxietyMultimodal dataCorrelatesTreatment responseTreatment outcomesDiverse relationsDisordersReviewThis reviewNegativityRecent FindingsRecent literatureRisk markersAdulthoodSuch workOutcomes
2021
Recent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildren
2020
Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth
Axelrud L, Simioni A, Pine D, Winkler A, Pan P, Sato J, Zugman A, Parker N, Picon F, Jackowski A, Hoexter M, Barker G, Martinot J, Martinot M, Satterthwaite T, Rohde L, Milham M, Barker E, Salum G. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth. European Child & Adolescent Psychiatry 2020, 30: 1895-1906. PMID: 33030612, PMCID: PMC9077631, DOI: 10.1007/s00787-020-01653-x.Peer-Reviewed Original ResearchConceptsGeneral psychopathologyCortical thicknessBrain featuresSubcortical volumesMental disordersStructural brain featuresInternal consistencyBrain structural featuresHealthy Brain NetworkPsychiatric disordersAssociation scoreSymptomatic domainsHigh internal consistencyPsychopathology assessmentDisordersBrain networksLow internal consistencyEffect sizeBehavioral phenotypesScoresReplicable associationsPsychopathologyWeighted scoreAssociationReplicable markersENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders
Bas‐Hoogendam J, Groenewold N, Aghajani M, Freitag G, Harrewijn A, Hilbert K, Jahanshad N, Thomopoulos S, Thompson P, Veltman D, Winkler A, Lueken U, Pine D, van der Wee N, Stein D, Agosta F, Åhs F, An I, Alberton B, Andreescu C, Asami T, Assaf M, Avery S, Nicholas L, Balderston, Barber J, Battaglia M, Bayram A, Beesdo‐Baum K, Benedetti F, Berta R, Björkstrand J, Blackford J, Blair J, Karina S, Blair, Boehme S, Brambilla P, Burkhouse K, Cano M, Canu E, Cardinale E, Cardoner N, Clauss J, Cividini C, Critchley H, Udo, Dannlowski, Deckert J, Demiralp T, Diefenbach G, Domschke K, Doruyter A, Dresler T, Erhardt A, Fallgatter A, Fañanás L, Brandee, Feola, Filippi C, Filippi M, Fonzo G, Forbes E, Fox N, Fredrikson M, Furmark T, Ge T, Gerber A, Gosnell S, Grabe H, Grotegerd D, Gur R, Gur R, Harmer C, Harper J, Heeren A, Hettema J, Hofmann D, Hofmann S, Jackowski A, Andreas, Jansen, Kaczkurkin A, Kingsley E, Kircher T, c M, Kreifelts B, Krug A, Larsen B, Lee S, Leehr E, Leibenluft E, Lochner C, Maggioni E, Makovac E, Mancini M, Manfro G, Månsson K, Meeten F, Michałowski J, Milrod B, Mühlberger A, Lilianne R, Mujica‐Parodi, Munjiza A, Mwangi B, Myers M, Nenadi C, Neufang S, Nielsen J, Oh H, Ottaviani C, Pan P, Pantazatos S, Martin P, Paulus, Perez‐Edgar K, Peñate W, Perino M, Peterburs J, Pfleiderer B, Phan K, Poletti S, Porta‐Casteràs D, Price R, Pujol J, Andrea, Reinecke, Rivero F, Roelofs K, Rosso I, Saemann P, Salas R, Salum G, Satterthwaite T, Schneier F, Schruers K, Schulz S, Schwarzmeier H, Seeger F, Smoller J, Soares J, Stark R, Stein M, Straube B, Straube T, Strawn J, Suarez‐Jimenez B, Boris, Suchan, Sylvester C, Talati A, Tamburo E, Tükel R, van den Heuvel O, Van der Auwera S, van Nieuwenhuizen H, van Tol M, van Velzen L, Bort C, Vermeiren R, Visser R, Volman I, Wannemüller A, Wendt J, Werwath K, Westenberg P, Wiemer J, Katharina, Wittfeld, Wu M, Yang Y, Zilverstand A, Zugman A, Zwiebel H. ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders. Human Brain Mapping 2020, 43: 83-112. PMID: 32618421, PMCID: PMC8805695, DOI: 10.1002/hbm.25100.Peer-Reviewed Original ResearchConceptsAnxiety disordersSocial anxiety disorderGeneralized anxiety disorderLarge-scale neuroimaging studiesNeuroscience methodologiesNeuroimaging studiesSpecific phobiaGlobal mental healthClinical neuroscienceMental healthPanic disorderENIGMA consortiumUnique sampleDisordersFuture directionsLow statistical powerSmall sample size
2015
Genetic Influence on the Human Brain
McKay D, Winkler A, Kochunov P, Knowles E, Sprooten E, Fox P, Blangero J, Glahn D. Genetic Influence on the Human Brain. Genome Mapping And Genomics In Animals 2015, 247-258. DOI: 10.1007/978-3-662-46306-2_13.Peer-Reviewed Original ResearchProgram of discoveryGenetic elementsGenetic underpinningsBasic neuroscienceBrain functionBrain structuresHuman brainGenetic influencesNeuroscienceNeuroscience componentFundamental neuroscienceGenetic search spacePrevalent disorderOverarching goalDiscoveryGenesSystematic programGeneticsImage-based featuresPhenotypeUnderpinningsMaturationLongevityDisordersImplications