2023
Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy
Casella C, Vecchiato K, Cromb D, Guo Y, Winkler A, Hughes E, Dillon L, Green E, Colford K, Egloff A, Siddiqui A, Price A, Grande L, Wood T, Malik S, Teixeira R, Carmichael D, O'Muircheartaigh J. Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy. Epilepsia 2023, 65: 739-752. PMID: 38088235, PMCID: PMC7616339, DOI: 10.1111/epi.17861.Peer-Reviewed Original ResearchDrug-resistant focal epilepsyFocal epilepsyMagnetic resonance imagingTreatment-related side effectsMRI-positive patientsMRI-negative patientsDisease severity measuresWidespread cortical areasPediatric focal epilepsyQuantitative magnetic resonance imagingPeriod of onsetTissue microstructural changesRadiological abnormalitiesUnderlying pathophysiologyHealthy controlsIndividual patientsCortical areasDisease processSide effectsPatientsFocal pathologyEpilepsyNeurobiological alterationsDisease severityResonance imaging
2019
Short-interval intracortical inhibition is decreased in restless legs syndrome across a range of severity
Magalhães S, Queiroz de Paiva J, Kaelin-Lang A, Sterr A, Eckeli A, Winkler A, Fernandes do Prado G, Amaro E, Conforto A. Short-interval intracortical inhibition is decreased in restless legs syndrome across a range of severity. Sleep Medicine 2019, 62: 34-42. PMID: 31539846, DOI: 10.1016/j.sleep.2019.03.021.Peer-Reviewed Original ResearchConceptsShort-interval intracortical inhibitionRLS/WEDCortical thicknessIntracortical inhibitionRestless legs syndrome/Willis-Ekbom diseaseRestless legs syndromePrimary motor cortexWillis-Ekbom diseaseCharacteristic curve analysisGray matter thicknessDiscrimination of participantsIdiopathic mildRange of severityLegs syndromeMotor cortexMagnetic resonance imaging dataMild symptomsSurface-based analysisSeverity ScaleCortical areasMagnetic stimulationWhole brainCurve analysisCharacteristic curveSeverity