2018
Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Donohue B, Kochunov P, Nichols TE. Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. Nature Communications 2018, 9: 3254. PMID: 30108209, PMCID: PMC6092439, DOI: 10.1038/s41467-018-05444-6.Peer-Reviewed Original Research
2015
Fast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimation