2022
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis
Bas-Hoogendam J, Bernstein R, Benson B, Buss K, Gunther K, Pérez-Edgar K, Salum G, Jackowski A, Bressan R, Zugman A, Degnan K, Filippi C, Fox N, Henderson H, Tang A, Zeytinoglu S, Harrewijn A, Hillegers M, White T, van IJzendoorn M, Schwartz C, Felicione J, DeYoung K, Shackman A, Smith J, Tillman R, van den Berg Y, Cillessen A, Roelofs K, Tyborowska A, Hill S, Battaglia M, Tettamanti M, Dougherty L, Jin J, Klein D, Leung H, Avery S, Blackford J, Clauss J, Hayden E, Liu P, Vandermeer M, Goldsmith H, Planalp E, Nichols T, Thompson P, Westenberg P, van der Wee N, Groenewold N, Stein D, Winkler A, Pine D, Group E. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: 1182-1188. PMID: 36038199, PMCID: PMC9434711, DOI: 10.1016/j.jaac.2022.04.023.Peer-Reviewed Original ResearchConceptsStructural brain correlatesSelf-report questionnairesTendency of individualsInhibited temperamentBehavioral inhibitionBrain correlatesUnfamiliar peopleDirect behavioral observationsEmotional tendencyTemperamentTemperament classificationEarly childhoodBehavioral observationsUnexpected eventsRetrospective levelsIndividualsUnfamiliarCorrelatesCaregiversTendencyRelateFirst yearChildhoodInfancyLife
2020
Infant behavioral reactivity predicts change in amygdala volume 12 years later
Filippi C, Sachs J, Phillips D, Winkler A, Gold A, Leibenluft E, Pine D, Fox N. Infant behavioral reactivity predicts change in amygdala volume 12 years later. Developmental Cognitive Neuroscience 2020, 42: 100776. PMID: 32452462, PMCID: PMC7096757, DOI: 10.1016/j.dcn.2020.100776.Peer-Reviewed Original ResearchConceptsYears of ageFour-month-old infantsAmygdala volumeBrain developmentAmygdala developmentPositive reactivityBehavioral reactivityStructural imagingInfant temperamentNovel evidenceChildhoodDistinct patternsCurrent studyMiddle childhoodYearsNegative reactivityReactive temperamentTemperamental reactivityInfants