2017
Hyperinsulinemia and elevated systolic blood pressure independently predict white matter hyperintensities with associated cognitive decrement in the middle-aged offspring of dementia patients
Hawkins KA, Emadi N, Pearlson GD, Winkler AM, Taylor B, Dulipsingh L, King D, Pittman B, Blank K. Hyperinsulinemia and elevated systolic blood pressure independently predict white matter hyperintensities with associated cognitive decrement in the middle-aged offspring of dementia patients. Metabolic Brain Disease 2017, 32: 849-857. PMID: 28255864, DOI: 10.1007/s11011-017-9980-9.Peer-Reviewed Original ResearchConceptsSystolic blood pressureWMH volumeVascular riskBlood pressurePlasma insulinDementia patientsMRI white matter hyperintensity volumeCognitive declineElevated systolic blood pressureSmall dense LDL-cholesterolWhite matter hyperintensity volumeH systolic BPIndependent risk factorDense LDL cholesterolCognitive decrementsBody mass indexWhite matter damageWhite matter hyperintensitiesApoE ε4 effectMiddle-aged offspringCerebral infarctsLifestyle modificationAggressive treatmentCerebrovascular damageLDL cholesterol
2013
Identification of Pleiotropic Genetic Effects on Obesity and Brain Anatomy
Curran JE, McKay DR, Winkler AM, Olvera RL, Carless MA, Dyer TD, Kent JW, Kochunov P, Sprooten E, Knowles EE, Comuzzie AG, Fox PT, Almasy L, Duggirala R, Blangero J, Glahn DC. Identification of Pleiotropic Genetic Effects on Obesity and Brain Anatomy. Human Heredity 2013, 75: 136-143. PMID: 24081229, PMCID: PMC3889074, DOI: 10.1159/000353953.Peer-Reviewed Original ResearchConceptsBody mass indexBrain anatomyEnergy homeostasisDevelopment of obesityLeptin-induced signalingCortical surface areaMass indexGut signalsChronic diseasesGlobal burdenObesitySubcortical volumesBiologic underpinningsReward circuitrySupramarginal gyrusGenetic factorsMexican-American individualsCommon genetic mechanismPleiotropic genetic effectsAnatomyBrainNeuroanatomical variationAmerican individualsCurrent knowledgePleiotropic effects