2017
Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols
Fey D, Aksamitiene E, Kiyatkin A, Kholodenko BN. Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols. Methods In Molecular Biology 2017, 1636: 417-453. PMID: 28730495, DOI: 10.1007/978-1-4939-7154-1_27.Peer-Reviewed Original ResearchConceptsReceptor tyrosine kinasesReceptor tyrosine kinase signalingMultiple cellular processesTyrosine kinase signalingCellular processesProtein phosphorylationKinase signalingNetwork biologySystems biologyTyrosine kinaseCell survivalIntegration of experimentsPowerful approachIntegrative approachBiologyComputational protocolQuantitative datasetsKinasePhosphorylationSignalingIdentification of salientApoptosisDifferentiationGlucose metabolismRegulation
2001
Temperature Dependence of the Epidermal Growth Factor Receptor Signaling Network Can Be Accounted for by a Kinetic Model †
Moehren G, Markevich N, Demin O, Kiyatkin A, Goryanin I, Hoek JB, Kholodenko BN. Temperature Dependence of the Epidermal Growth Factor Receptor Signaling Network Can Be Accounted for by a Kinetic Model †. Biochemistry 2001, 41: 306-320. PMID: 11772030, DOI: 10.1021/bi011506c.Peer-Reviewed Original ResearchConceptsEpidermal growth factorEGF receptorEGFR kinaseDomain-mediated interactionsEGF receptor dimerizationProtein-protein interactionsRapid tyrosine phosphorylationMultiple signaling proteinsEGFR kinase activityReceptor phosphataseSignaling networksSignaling proteinsProtein interactionsPhosphorylation patternTyrosine phosphorylationReceptor dimerizationKinase activityTarget proteinsMembrane lipidsMolecular termsDephosphorylation reactionsEGFR pathwayPhosphataseKinasePhosphorylation
1995
Control of erythrocyte metabolism by redox-regulated tyrosine phosphatases and kinases
Low P, Kiyatkin A, Li Q, Harrison M. Control of erythrocyte metabolism by redox-regulated tyrosine phosphatases and kinases. Protoplasma 1995, 184: 196-202. DOI: 10.1007/bf01276920.Peer-Reviewed Original ResearchTyrosine phosphataseN-terminusBand 3Cytoplasmic tyrosine phosphataseGlyceraldehyde-3-phosphate dehydrogenase bindsEnzyme bindingCytoplasmic domainTyrosine phosphorylationTyr-8Tyrosine kinaseElectron transport pathwaysGlycolytic enzymesMetabolic regulationCoordinate mannerTyr-21KinaseNovel mechanismPhosphorylationRedox changesPhosphataseFull activityTransport pathwaysEnzymePathwayBinding